ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
Association between the triglyceride
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
objectivesCardiovascular disease (CVD) is one of the major chronic non-communicable diseases worldwide, with high incidence and mortality. This study aims to investigate the association of the triglyceride-glucose index-to-waist-to-height ratio (TyGI-WHtR) with CVD and its subtypes [myocardial infarction (MI) and stroke] in middle-aged and older Chinese adults.
methodsThis prospective cohort study was based on 3 follow-up surveys of the China Health and Nutrition Survey (CHNS) from 2009 to 2015. A total of 5 395 participants aged 40 to 80 years who were free of CVD at baseline and had participated in at least 2 survey waves were included. Cox proportional hazards models were used to evaluate the associations of TyGI-WHtR with CVD and its subtypes. Weighted generalized additive models and smooth curve fitting were applied to explore potential nonlinear relationships. Time-dependent receiver operating characteristic (ROC) curves assessed predictive performance, and Kaplan-Meier analysis was used to calculate cumulative incidence of CVD across different groups.
resultsDuring a median follow-up of 72 months (interquartile range: 48 to 72 months), 210 incident CVD events were recorded, including 126 strokes and 92 MIs. Among them, 8 patients had both MI and stroke. After adjustment for confounders, each one-standard-deviation (SD) increase in TyGI-WHtR was associated with a significantly higher risk of incident CVD [adjusted hazard ratio (
conclusionsIn middle-aged and older Chinese adults, TyGI-WHtR is an independent risk factor for incident CVD, particularly MI, but is not independently associated with stroke. Moreover, its predictive ability for CVD demonstrates a nonlinear saturation-threshold effect, with risk significantly increased only when TyGI-WHtR is below 4.804.
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