ReviewZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026
[Research progress on the metabolic regulatory mechanisms of coronary collateral circulation].
Review in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Coronary collateral circulation (CCC) develops in response to coronary artery stenosis or occlusion and helps maintain myocardial perfusion and attenuate ischemic injury. Shear stress and signaling pathways play crucial roles in collateral vessel formation, while metabolic status is a key determinant of individual variability in collateral growth capacity. In recent years, metabolic reprogramming has been recognized as a fundamental basis for endothelial plasticity and vascular regenerative potential. Glycolysis, fatty acid oxidation, and mitochondrial metabolism play essential roles in endothelial cell migration, proliferation, and redox homeostasis. Aging and metabolic disorders impair collateral vessel formation by disrupting these metabolic pathways. Immunometabolism also profoundly influences coronary collateral circulation, with M2 macrophages promoting angiogenesis through fatty acid oxidation. Energy metabolism, aging-related metabolic dysfunction, and immunometabolism all affect the development of coronary collateral circulation. Metabolic intervention strategies may therefore enhance collateral vessel formation in ischemic heart disease.
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