Evidence map›Paper›PMID 42394776›Full record

ReviewWorld journal of experimental medicine2026

Genetic and biological determinants of pulmonary embolism: Insights from Mendelian randomization studies.

Rupak Desai, Darsh Patel, Abhishek Prasad, Navya Mandalapu, Jai Nagarajan, Ananth Guddeti, Sourabh Khatri, Warda Shahnawaz, Abdul Aleem, Adil S Mohammed and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rupak DesaiOutcomes Research, Independent Researcher, Atlanta, GA 30033, United States.
Darsh PatelDepartment of Medicine, Mercy Catholic Medical Center, Darby, PA 19023, United States.
Abhishek PrasadDepartment of Anesthesiology and Perioperative Medicine, MD Anderson Cancer Center, Houston, TX 77030, United States.
Navya MandalapuDepartment of Medicine, BronxCare Health Sciences, Bronx, NY 10457, United States.
Jai NagarajanDepartment of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, United States.
Ananth GuddetiDepartment of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, United States.
Sourabh KhatriDepartment of Medicine, Independence Health System, Greensburg, PA 15601, United States.
Warda ShahnawazDepartment of Medicine, Mobile Infirmary Medical Center, Mobile, AL 36604, United States.
Abdul AleemPulmonary and Critical Care Medicine, Henry Ford Health-Genesys Hospital, Grand Blanc, MI 48439, United States.
Adil S MohammedDepartment of Medicine, Central Michigan University, Saginaw, MI 48602, United States.
Umera YasmeenDepartment of Medicine, Mamata Medical College, Rotary Nagar 507002, Khammam, India.
Muhammad Usman GhaniDepartment of Medicine, Central Michigan University, Saginaw, MI 48602, United States. usmanghani162@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary embolism (PE) is a common and potentially fatal thromboembolic disease contributing to a major global public health burden. Its pathogenesis involves multiple hemodynamic, inflammatory, metabolic, and genetic factors. The multifactorial nature of PE makes it difficult to infer the direct effects of risk factors using conventional statistical approaches because of potential confounding and reverse causality. Mendelian randomization (MR) uses genetic variants as instrumental variables to strengthen causal inference. This narrative review synthesizes the available MR literature concerning potential causative factors of PE, with particular emphasis on genetic and biological pathways. MR evidence suggests that matrix metalloproteinases (MMP)-19 may be associated with increased PE susceptibility, whereas MMP-12 may be associated with decreased susceptibility. Impaired kidney function showed a positive association with PE risk, and reduced HLA-DR

Indexed as

Genetic epidemiologyImmune dysregulationMatrix metalloproteinasesMendelian randomizationPulmonary embolismRenal dysfunctionRisk factorsThrombosis

Identifiers

PMID42394776
PMCPMC13323850

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.