ArticleChemical science2026
Guiding point-of-care therapeutic drug monitoring through structure-toxicity principles.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
A structure-toxicity strategy was employed to generate monoclonal antibodies exhibiting a gradient of affinity corresponding to the toxicity level of biguanides, and an immunochromatographic sensor was established for diabetes drug risk monitoring, enabling a therapeutic drug monitoring function that can accurately identify high-risk biguanides in human serum. The data demonstrated that the H1-induced monoclonal antibody 2G8 was generated with the ability to recognize biguanides according to the toxicity gradient (affinity gradient: phenformin > buformin > moroxydine > metformin), with IC
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Registered trials
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