SynthesisFrontiers in cellular and infection microbiology2026
Distinctive reproductive tract microbial characteristics associated with infertility in women: a systematic review and meta-analysis.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Objective: To evaluate α-diversity alterations, summarize microbial taxa reported to be associated with infertility, and examine site-specific differences in reproductive tract microbiota between infertile and fertile women via systematic review and meta-analysis. Data sources: Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science were searched from inception to December 30, 2025, supplemented by clinical trial registries, conference proceedings, and manual reference screening. Study eligibility criteria: Observational studies (cross-sectional, case-control, cohort) including women 18-45 years with infertility versus healthy fertile controls, using high-throughput sequencing of reproductive tract microbiota, reporting α-diversity or taxa abundance. Excluded randomized controlled trials (RCTs), animals, reviews. Study appraisal and synthesis methods: PRISMA-compliant review. The Newcastle-Ottawa Scale (NOS) for quality, the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) for evidence. Random-effects meta-analysis with standardized mean differences (SMD) and 95% credible interval (CrI); I² for heterogeneity; subgroup and sensitivity analyses by site. Results: Twenty-seven studies with 2174 participants were included. Infertile women had higher α-diversity (Shannon SMD 0.27 [0.10 to 0.44; I² = 40%], Simpson SMD 0.24 [0.01 to 0.47; I² = 52%], ACE SMD 0.43 [0.15 to 0.71; I² = 33%]). Conclusions: Infertile women show site-specific microbiota patterns, including reduced Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251275219.
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