ReviewFrontiers in neurology
Sleep deprivation: a comprehensive review of multisystem impacts, underlying mechanisms, and emerging interventions.
Review in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Sleep deprivation (SD) has become a pervasive public health issue with significant ramifications for physiological and cognitive function. This review aims to provide a comprehensive synthesis of the detrimental health effects of SD, explore the underlying pathophysiological mechanisms, and evaluate current and emerging intervention strategies. We conducted a narrative review of the literature, synthesizing findings from epidemiological, clinical, and preclinical studies. The results indicate that SD profoundly disrupts the function of multiple organ systems, including the nervous, cardiovascular, respiratory, digestive, immune, and endocrine systems. At the mechanistic level, SD induces neuroinflammation, disrupts the intestinal barrier and gut microbiota, impairs hippocampal structure and function, and alters synaptic plasticity. Interventions span pharmacological approaches-from traditional central nervous system stimulants (e.g., caffeine, amphetamines, and modafinil) and sedative-hypnotics to novel therapies such as orexin receptor antagonists and gut microbiota modulators-and non-pharmacological strategies, including napping, physical therapies (e.g., transcranial magnetic stimulation, and light therapy), exercise, cognitive behavioral therapy, and dietary modifications. In conclusion, the evidence highlights the crucial role of adequate sleep in maintaining health. A multifaceted approach combining pharmacological and non-pharmacological interventions, tailored to individual and population-specific needs, holds the greatest promise for mitigating the adverse effects of SD. Future research should focus on personalized interventions and leverage advanced technologies to elucidate the pathogenesis of SD further and develop more effective countermeasures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.