Evidence map›Paper›PMID 42395008›Full record

ArticleJournal of ginseng research2026

Gintonin prevents paclitaxel-induced neuropathic pain via spinal LPA

Keun-Tae Park, Heejoon Jo, Seung-Yeol Nah, Young-Ho Jin, Ik-Hyun Cho, Woojin Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keun-Tae ParkDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Heejoon JoDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Seung-Yeol NahDepartment of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, 05029, Republic of Korea.
Young-Ho JinDepartment of Physiology, School of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Ik-Hyun ChoDepartment of Convergence Medical Science, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Woojin KimDepartment of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chemotherapy-induced peripheral neuropathy (CIPN) remains a major clinical challenge with limited treatment options. Gintonin, a glycolipoprotein complex derived from Methods: Gintonin (50-200 mg/kg, p.o.) was repeatedly administered in a paclitaxel-induced neuropathic pain model. Mechanical and cold allodynia were assessed, and spinal tissues were analyzed for LPA receptor expression. Receptor-specific siRNAs were intrathecally delivered to identify the subtype involved. Immunofluorescence and Cy5.5-labeled gintonin were used to examine LPA Results: Gintonin attenuated paclitaxel-induced mechanical and cold allodynia, with the greatest effects observed at 100 and 200 mg/kg, and upregulated spinal gene expression of LPA Conclusion: These findings suggest that gintonin prevents paclitaxel-induced neuropathic pain through LPA

Indexed as

Antinociceptive effectGintoninLysophosphatidic acid receptorNeuropathic painOligodendrocyte precursor cellPaclitaxelPanax ginseng

Identifiers

PMID42395008
PMCPMC13323891

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.