Evidence map›Paper›PMID 42395016›Full record

ArticleJournal of ginseng research2026

Ginsenoside Rg1 enhances stem cell abundance in aging human skeletal muscle after resistance exercise.

Andrew Nicholls, Giancarlo Condello, Chih-Yang Huang, Li-Fan Lai, Luthfia Dewi, Yu-Chieh Liao, Li-Ning Peng, Liang-Kung Chen, Tse-Chun Kuo, Hsing-Jien Kung and 2 more

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In one paragraph

Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew NichollsLaboratory of Exercise Biochemistry, University of Taipei, Taipei, 11153, Taiwan.
Giancarlo CondelloDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Chih-Yang HuangCardiovascular and Mitochondria Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Li-Fan LaiLaboratory of Exercise Biochemistry, University of Taipei, Taipei, 11153, Taiwan.
Luthfia DewiDepartment of Nutrition, Universitas Muhammadiyah Semarang, Semarang, 50273, Indonesia.
Yu-Chieh LiaoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, 11153, Taiwan.
Li-Ning PengCenter for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
Liang-Kung ChenCenter for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan.
Tse-Chun KuoGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Hsing-Jien KungGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Wei-Horng JeanDepartment of Anesthesiology, Far East Memorial Hospital, New Taipei City, 220, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, 11153, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ginsenoside Rg1 enhances senolytic effect of exercise in human skeletal muscle. Purpose: To determine the effects of Rg1 on stem cell enrichment and differentiation in skeletal muscle following resistance exercise in women over 60. Methods: In a randomized, double-blind, placebo-controlled crossover trial, 11 women (60-73 years) completed four sets of seated leg press (70% 1RM) 1 h after ingesting Placebo or Rg1 (10 mg). Muscle biopsies were assessed for activated mesenchymal stem cells (Stro-1 Results: While exercise alone did not alter Stro-1 Conclusion: Rg1 supplementation prevents exercise-induced sex steroid depletion and markedly enhances stem cell abundance in skeletal muscle, which contributes to mitochondrial gains following resistance exercise in women over 60.

Identifiers

PMID42395016
PMCPMC13323887

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.