ArticleJournal of ginseng research2026
Effect of Korean red ginseng on deep capillary plexus parameters in diabetic retinopathy: A prospective, randomized, double-blind clinical trial.
Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This prospective, randomized, double-blind clinical trial aimed to evaluate the effects of Korean Red Ginseng (KRG) extract on the retinal microvascular parameters in patients with diabetic retinopathy (DR). Methods: Patients with mild to moderate non-proliferative DR were randomized to receive KRG extract or placebo for 90 days. Outcomes included changes in the best-corrected visual acuity (BCVA), intraocular pressure (IOP), central macular thickness (CMT), and optical coherence tomography angiography (OCTA) parameters, including the foveal avascular zone, vessel length density (VLD), and perfusion index (PI) in the superficial and deep capillary plexuses (SCP and DCP, respectively). The incidence of proliferative DR or diabetic macular edema (DME) was also monitored. Results: Twenty-four patients were enrolled and 23 completed the study. The baseline BCVA, IOP, CMT, and OCTA parameters were comparable between the groups (all p > 0.05). No significant changes were observed in BCVA, CMT, DR severity stage, or incidence of DME over the 3-month follow-up period in either group. Significant group × time interaction effects were observed for inferior DCP VLD (p = 0.011) and for PI in the superior (p = 0.044) and inferior (p = 0.026) DCP regions. No significant interaction effects were identified for SCP parameters or other DCP subfields. No adverse events were reported. Conclusions: KRG extract was associated with short-term, region-specific changes in OCTA-derived DCP perfusion metrics over 3 months. These findings reflect alterations in OCTA-derived microvascular parameters and do not establish modification of clinical outcomes such as DR progression or the development of DME. Trial registration: Clinical Research Information Service, #KCT0010991.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.