Evidence map›Paper›PMID 42395032›Full record

ArticleBrain, behavior, & immunity - health2026

Inflammatory, metabolic, and vascular pathways linking cardiorespiratory fitness to cognition: Results from the IGNITE study.

Patricio Solis-Urra, Kelsey R Sewell, Audrey M Collins, Chaeryon Kang, Haiqing Huang, George Grove, Lu Wan, Amani M Norling, Arthur F Kramer, Edward McAuley and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Patricio Solis-UrraAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.
Kelsey R SewellAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.
Audrey M CollinsAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.
Chaeryon KangDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Haiqing HuangAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.
George GroveDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Lu WanAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.
Amani M NorlingAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.
Arthur F KramerBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, IL, 61801, USA.
Edward McAuleyBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, IL, 61801, USA.
Jeffrey M BurnsAlzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Charles H HillmanDepartment of Psychology, Northeastern University, Boston, MA, 02115, USA.
Eric D VidoniAlzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Anna L MarslandDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
M Ilyas KambohDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Amanda Szabo-ReedDepartment of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.
Renee J RogersDepartment of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Daniel E FormanDepartment of Medicine (Cardiology and Geriatrics), University of Pittsburgh, and Pittsburgh Geriatrics, Research, Education and Clinical Care (GRECC), Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Sandra A BillingerAlzheimer's Disease Research Center, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
John M JakicicDepartment of Internal Medicine, Division of Physical Activity and Weight Management, University of Kansas Medical Center, Kansas City, KS, 66160, USA.
Kirk I EricksonAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.
Lauren E OberlinAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study examined whether peripheral biological pathways including inflammation, insulin resistance, and arterial stiffness, partially explain the link between cardiorespiratory fitness (CRF) and cognitive function in older adults. Methods: In a cross-sectional sample of cognitively unimpaired older adults (N = 648, 71% female, M age = 69.88 Results: IL-6 emerged as a consistent significant mediator of the relationship between CRF and EF, episodic memory, visuospatial processing and working memory. HOMA-IR statistically mediated the association between CRF and both EF and processing speed. In contrast, cfPWV did not statistically mediate an association between CRF and performance in any cognitive domain. Conclusion: These findings suggest that low-grade systemic inflammation broadly mediates the relationship between CRF and cognitive function, while metabolic pathways show more domain-specific associations. Together, these results highlight the need for understanding the plural, yet distinct, biological mechanisms by which higher CRF relates to better cognitive performance, with the goal of identifying potential targets for interventions aimed at preserving cognitive health in older adulthood.

Identifiers

PMID42395032
PMCPMC13324667

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.