Evidence map›Paper›PMID 42395075›Full record

ArticleAmerican journal of preventive cardiology2026

Impact of resistance training for lowering blood pressure in older adults.

Deepika Laddu, Xuan Cai, Adam D Gepner, Christopher W Sundberg, Norinna B Allen, Jun Ma, Shane A Phillips

Abstract read
In one paragraph

Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Resistance training in older adults: are the gains worth the strain?American journal of preventive cardiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Deepika LadduDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Xuan CaiDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Adam D GepnerWilliam S. Middleton Memorial Veteran's Hospital, Department of Medicine - Division of Cardiovascular Medicine, Madison, WI, USA.
Christopher W SundbergUniversity of Wisconsin School of Medicine and Public Health, Department of Medicine - Division of Geriatrics & Gerontology, Madison, WI, USA.
Norinna B AllenDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Jun MaDepartment of Medicine, University of Illinois Chicago, Chicago, Illinois, USA.
Shane A PhillipsDepartment of Physical therapy, University of Illinois Chicago, Chicago, Illinois, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The INERTIA study evaluated the preliminary effects of a 12-week progressive resistance training (PRT) intervention on changes in blood pressure (BP) in older adults. Methods: Older adults (≥60 years) with low muscle strength and no diagnosed CVD were randomized (2:1) to 12 weeks of PRT (n=50) or assessment-only control (n=21). The primary outcome was between-group difference in 12-week changes in systolic (SBP) and diastolic BP (DBP). Secondary outcomes were changes in muscle strength (chest press, leg press), and physical function (short-physical performance battery, SPPB). Two-way repeated measures ANOVA assessed between-group effects (LS mean) and within-group changes. Results: Seventy-one participants (mean (SD); age, 70.1 (6.3) years); 76% female, 43% non-white; 42% on antihypertensive therapy) enrolled, and 61 completed follow-up. Baseline SBP/DBP was 130 (20.2)/82 (12.3) mmHg. Compared with control, PRT produced greater reductions for DBP (difference in change, -4.2 mmHg; 95% CI -8.3, -0.1), but not for SBP (-5.4 mmHg; 95% CI -13.0, 2.2). Within the PRT group, SBP (mean change -5.6 mmHg; 95% CI -11.1, -0.1) and DBP (-3.9 mmHg; 95% CI -6.8, -0.9) decreased significantly, with minimal change in controls. Strength gains (chest press, 11.0 kg; leg press, 63.6 kg) were greater in PRT than controls (all p<0.001), while between-group improvements in SPPB (PRT: 2 points, controls: 1.2 points) were not significant. Conclusion: In older adults, PRT significantly increased muscle strength and reduced DBP beyond controls, with a trend towards clinically meaningful improvements in SBP and physical function. Larger, adequately powered trials are warranted to confirm these findings.

Indexed as

Blood pressureHypertensionMuscle strengthOlder adultsResistance training

Identifiers

PMID42395075
PMCPMC13325988

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.