Evidence mapPaperPMID 42395079Full record

ArticleAmerican journal of preventive cardiology2026

Phenogroup-based stratification of cardiovascular risk in obstructive sleep apnea.

Anastasya Maria Kosasih, Yihui Ou, Chieh-Yang Koo, Luciano F Drager, Junjie Zhang, Rishi Sethi, Ruogu Li, Hee-Hwa Ho, Germaine Loo, Thun-How Ong and 14 more

Abstract read
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Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Anastasya Maria KosasihDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Yihui OuDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Chieh-Yang KooDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Luciano F DragerHypertension Unit-Heart Institute (InCor), University of Sao Paulo Medical School, Brazil.
Junjie ZhangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, China.
Rishi SethiDepartment of Cardiology, King George's Medical University, Lucknow, India.
Ruogu LiDepartment of Cardiology, Shanghai Chest Hospital, China.
Hee-Hwa HoDepartment of Cardiology, Tan Tock Seng Hospital, Singapore.
Germaine LooDepartment of Cardiology, National Heart Centre, Singapore.
Thun-How OngDepartment of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.
Ching-Hui SiaDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Zhengfeng ChenDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Hui-Wen SimDepartment of Cardiology, Ng Teng Fong General Hospital, Singapore.
Giap-Swee KangDepartment of Cardiac, Thoracic, and Vascular Surgery, National University Heart Centre, Singapore.
Vitaly SorokinDepartment of Cardiac, Thoracic, and Vascular Surgery, National University Heart Centre, Singapore.
Serene WongDepartment of Medicine, Alexandra Hospital, Singapore.
Nicholas ChewDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Mark Y ChanDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Arthur Mark RichardsChristchurch Heart Institute, University of Otago, Dunedin, New Zealand.
Shao-Liang ChenHypertension Unit-Heart Institute (InCor), University of Sao Paulo Medical School, Brazil.
Huay-Cheem TanDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.
Ferran BarbeTranslational Research in Respiratory Medicine, University Hospital Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.
Wilson W TamAlice Lee Centre for Nursing Studies, National University of Singapore, Singapore.
Chi-Hang LeeDepartment of Cardiology, National University Heart Centre, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obstructive sleep apnea (OSA) exhibits substantial phenotypic heterogeneity, but its prognostic relevance in patients with coronary artery disease (CAD) undergoing revascularization remains uncertain. Methods: We pooled data from two prospective cohorts of CAD patients undergoing percutaneous coronary intervention or coronary artery bypass grafting ( Results: Three phenogroups were identified: (1) Younger-Sleepy-Hypoxia (42.2%), (2) Cardiorenal-Metabolic (30.9%), and (3) Old-Lean-Chinese (26.9%). OSA prevalence was similar across groups (45.5%, 50.7%, and 47.8%). The overall incidence of MACCE was 11.4% and did not differ significantly across phenogroups ( Conclusions: In revascularized CAD patients, OSA was associated with increased cardiovascular risk in the overall cohort, with heterogeneity across phenogroups. These findings support phenogroup-based risk stratification, pending external validation.

Indexed as

Coronary artery diseasePhenogroupRisk predictionSleep apnea

Identifiers

PMID42395079
PMCPMC13326126

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.