ArticleAmerican journal of preventive cardiology2026
Trajectories of blood pressure and influencing factors across menopause: A longitudinal cohort study.
Article in American journal of preventive cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To identify the trajectories of blood pressure (BP) across menopause in Chinese women and analyze influencing factors. Methods: A total of 526 participants, contributing 4759 measurements, from the Peking Union Medical College Hospital Aging Longitudinal Cohort of Women in Midlife were included in this analysis. Group-based trajectory modeling was used to identify distinct trajectories of systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) changes across menopause. Logistic regression and mixed-effects models were used to analyze the associations between sex hormones, body mass index (BMI), waist circumference(WC) and BP trajectories. Sensitivity analyses were conducted on participants who still have natural menstrual cycle at enrollment. Results: Three distinct trajectories were identified for SBP, DBP and MAP. Overall, SBP and MAP exhibited an upward trend, while DBP showed a downward trend. For all three parameters, lower estradiol was correlated negatively to BP in the "high" group. But BMI and WC had a significant positive correlations of changes in BP in all three groups. BMI and WC exhibited a negative interactions in influencing BP. Additionally, SBP, DBP and MAP were higher in the "high" BMI trajectory group compared to the remaining two groups. Sensitivity analysis also showed similar findings as that from all the participants. Conclusion: Chinese women across menopause experience distinct trajectories for SBP, DBP and MAP, influenced by BMI and WC. This further underscores the necessity for enhanced BP monitoring and weight management among perimenopausal women to promote long-term cardiovascular health.
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