Evidence map›Paper›PMID 42395170›Full record

ArticleAddiction neuroscience2025

Corticotrophin-releasing hormone binding protein in the basolateral amygdala: divergent roles in cocaine and opioid addiction like behaviors.

Courtney P Wood, Arnav Gurha, Caitlin Crook, Angelica Martinez, Selen Dirik, Cloe Moreno, Anirudh Vaiyapuri, Avraham Libster, Francesca Telese, Giordano de Guglielmo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Courtney P WoodPsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.ORCID 0000-0003-2263-1818
Arnav GurhaPsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Caitlin CrookPsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Angelica MartinezPsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Selen DirikPsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Cloe MorenoPsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Anirudh VaiyapuriPsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Avraham LibsterPsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.
Francesca TelesePsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.ORCID 0000-0003-3877-0628
Giordano de GuglielmoPsychiatry Department, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-4782-7430

Funding

Decoding the grammar of transcriptional enhancers regulating different stages of opioid use disorderU01DA051972 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BENNER, CHRISTOPHER W, TELESE, FRANCESCA · 2020 to 2024
$3.4M
Multiomic profiling of cell types mediating opioid use disorder in ratsR01DA056602 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Giordano De Guglielmo, Francesca Telese · 2022 to 2026
$3.0M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NIDA NIH HHS R01 DA056602NIDA NIH HHS U01 DA051972NIH HHS S10 OD026929
6 · The paper itself

Abstract

Cocaine and oxycodone use disorders represent urgent public health burdens, with limited treatment options for opioid dependence and no approved pharmacotherapies for cocaine-related disorders, highlighting the critical need to uncover novel molecular targets in the addiction neurocircuitry. The basolateral amygdala (BLA) modulates withdrawal and drug-seeking behaviors in substance use disorders (SUDs), but the molecular drivers of these effects are poorly understood. Here, we investigated the role of corticotrophin-releasing hormone binding protein (CRHBP) in the BLA using viral-mediated knockdown, single-nucleus RNA sequencing (snRNA-seq), and operant self-administration in rats. snRNA-seq revealed

Indexed as

AddictionAmygdalaCocaineCorticotrophin-releasing binding proteinOxycodone

Identifiers

PMID42395170
PMCPMC13327722

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.