ReviewCureus2026
Mapping the Oral Microbiome's Role in Periodontal Disease Progression: A Systematic Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal disease is an inflammatory condition characterized by progressive destruction of the tooth-supporting tissues and a shift from a symbiotic to a dysbiotic oral microbial community, rather than by a single pathogen. This review aimed to synthesize current evidence on how alterations in microbial composition, community structure, and functional activity contribute to periodontal disease severity and progression. A comprehensive literature search across four databases (PubMed, Web of Science, Google Scholar, and Embase) was conducted. Studies were included if they were peer-reviewed, human studies published between 2000 and 2026, and met the predefined inclusion and exclusion criteria. Twenty-two articles met these criteria and were analyzed for relationships between microbial patterns and clinical peritoneal outcomes. Across the studies reviewed, periodontal disease severity was consistently associated with compositional shifts in the oral microbiome rather than changes in overall microbial diversity or bacterial load. Increased prevalence and abundance of red-complex organisms, including
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.