Arterial calcification due to CD73 deficiency presenting with critical limb-threatening ischemia successfully treated with iliac endarterectomy and distal bypass.

Yusuke Kato, Etsuko Hisanaga, Takuya Koyano, Naoki Konno, Hayato Ikota, Wataru Tatsuishi

Abstract readCase Reports

In one paragraph

Article in Journal of vascular surgery cases and innovative techniques, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Yusuke KatoDivision of Cardiovascular Surgery, Department of General Surgical Science, Gunma University, Maebashi, Gunma, Japan.

Etsuko HisanagaClinical Department of Pathology, Gunma University, Maebashi, Gunma, Japan.

Takuya KoyanoDivision of Cardiovascular Surgery, Department of General Surgical Science, Gunma University, Maebashi, Gunma, Japan.

Naoki KonnoDivision of Cardiovascular Surgery, Department of General Surgical Science, Gunma University, Maebashi, Gunma, Japan.

Hayato IkotaClinical Department of Pathology, Gunma University, Maebashi, Gunma, Japan.

Wataru TatsuishiDivision of Cardiovascular Surgery, Department of General Surgical Science, Gunma University, Maebashi, Gunma, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arterial calcification due to CD73 deficiency is a rare disorder causing progressive medial calcification. Revascularization reports remain scarce. We describe a 67-year-old woman with arterial calcification due to CD73 deficiency and critical limb-threatening ischemia. Because endovascular therapy was unfeasible due to extensive calcification, we performed external iliac artery endarterectomy and anterior tibial artery bypass. Despite near-complete medial calcification, the adventitia allowed secure anastomosis. Postoperative imaging confirmed graft patency, and improved perfusion facilitated forefoot healing. Surgical reconstruction offers a viable option for limb salvage when endovascular therapy is precluded.

Indexed as

AmputationArterial bypassArterial calcificationEndarterectomyPerfusion

Identifiers

PMID42395260

DOI10.1016/j.jvscit.2026.102331

PMCPMC13325284

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.