Evidence map›Paper›PMID 42395337›Full record

ArticleBioactive materials2026

Intelligent responsive alloy scaffold temporally regulates the immune-osteogenic axis for the treatment of infectious bone defects.

Dong Ruan, Zhiqiang Li, Xueqiang Deng, Hui Jiang, Xiaoyong Lan, Xiang Chen, Chengpeng Qiu, Foqiang Liao, Jiale Zhu, MingChuan Yu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dong RuanDepartment of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Zhiqiang LiDepartment of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Xueqiang DengDepartment of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Hui JiangDepartment of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Xiaoyong LanDepartment of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Xiang ChenDepartment of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Chengpeng QiuDepartment of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Foqiang LiaoDepartment of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Jiale ZhuThe Second Clinical Medical College, Nanchang University, Jiangxi, 330006, PR China.
MingChuan YuDepartment of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
Jilin XuSchool of Materials Science and Engineering, Guangdong Ocean University, Yangjiang, Guangdong, 529500, PR China.
Jun LuoDepartment of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive immune activation induced by persistent bacterial infection, which further impairs osteogenic function, is a crucial factor contributing to the poor healing of infectious bone defects. Therapeutic strategies targeting a single link often yield limited efficacy. Therefore, we developed an alloy scaffold bone graft (TCMP) with pH-responsive sequential regulation of the immuno-osteogenic axis. During the infection phase, the scaffold mainly releases copper ions to exert potent antibacterial activity, and simultaneously releases

Indexed as

AGEs/RAGE/NF-κB pathwayAlloy scaffoldHIF-1 signaling pathwayImmune-osteogenic axisInfectious bone defectTemporal regulation

Identifiers

PMID42395337
PMCPMC13324309

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.