Evidence map›Paper›PMID 42395378›Full record

ArticlebioRxiv : the preprint server for biology2026

Cognitive and affective neurodevelopment in youth exposed to deprivation and threat.

Omid Kardan, Mike Angstadt, M Fiona Molloy, Elisa M Trucco, Mary M Heitzeg, Katherine L McCurry

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Omid KardanUniversity of Michigan, Department of Psychiatry; Ann Arbor, MI.ORCID 0000-0003-4187-5228
Mike AngstadtUniversity of Michigan, Department of Psychiatry; Ann Arbor, MI.ORCID 0000-0003-4870-7649
M Fiona MolloyUniversity of Michigan, Department of Psychiatry; Ann Arbor, MI.
Elisa M TruccoUniversity of Michigan, Department of Psychiatry; Ann Arbor, MI.ORCID 0000-0002-9922-8608
Mary M HeitzegUniversity of Michigan, Department of Psychiatry; Ann Arbor, MI.ORCID 0000-0002-6737-2971
Katherine L McCurryUniversity of Michigan, Department of Psychiatry; Ann Arbor, MI.ORCID 0000-0001-6921-7636

Funding

Environmental Influences on Neurocognitive Development of Control and Adolescent Substance UseK01DA059598 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Omid Kardan · 2024 to 2026
$547k
Modeling and modulating neural responses to reward and threat: Associations with childhood adversity and risk for substance use problemsK23DA060996 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Katherine McCurry · 2025 to 2026
$393k
NIDA NIH HHS K01 DA059598NIDA NIH HHS K23 DA060996
6 · The paper itself

Abstract

Background: Early life adversity (ELA) is associated with notable negative consequences across development. Experiences of deprivation may affect neurocognitive development, while experiences of threat may alter emotion processing. Deprivation and threat may also differentially influence reward processing. However, unique consequences of deprivation and threat beyond low family resources are debated. Methods: We employed an exposure vs. control data analytic approach to isolate deprivation and threat influences from socioeconomic resources. Adolescent Brain Cognitive Development (ABCD Results: In the Conclusion: Both threat and deprivation exposure during childhood may delay neurocognitive development in early adolescence beyond their co-occurrence with low socioeconomic resources.

Indexed as

DeprivationEarly adolescenceEarly life adversityNeurocognitive maturationReward processingThreatThreat processing

Identifiers

PMID42395378
PMCPMC13320750

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.