Evidence map›Paper›PMID 42395477›Full record

ArticlebioRxiv : the preprint server for biology2026

Ventral pallidal GABAergic neurons control hedonic feeding and obesity.

Justin G Wang, Chang S Xu, Chantelle L Murrell, Mason R Barrett, Gargi C Basu, Lisa Z Fang, Yiru Chen, Florian Schoukroun, Thomas Topilko, Johanna Perens and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Justin G WangDepartment of Psychiatry, Washington University in St. Louis, St. Louis MO, USA.ORCID 0000-0003-4730-627X
Chang S XuDepartment of Anesthesiology, Washington University in St. Louis, St. Louis MO, USA.ORCID 0000-0003-0919-8634
Chantelle L MurrellDepartment of Psychiatry, Washington University in St. Louis, St. Louis MO, USA.ORCID 0009-0004-4678-0601
Mason R BarrettDepartment of Psychiatry, Washington University in St. Louis, St. Louis MO, USA.ORCID 0009-0002-2941-4859
Gargi C BasuDepartment of Psychiatry, Washington University in St. Louis, St. Louis MO, USA.ORCID 0000-0003-2918-7895
Lisa Z FangDepartment of Anesthesiology, Washington University in St. Louis, St. Louis MO, USA.ORCID 0000-0001-5742-0864
Yiru ChenDepartment of Psychiatry, Washington University in St. Louis, St. Louis MO, USA.ORCID 0000-0001-6144-5888
Florian SchoukrounDepartment of Psychiatry, Washington University in St. Louis, St. Louis MO, USA.ORCID 0009-0002-1128-2157
Thomas TopilkoVibraint ApS, Frederiksberg, Denmark.
Johanna PerensVibraint ApS, Frederiksberg, Denmark.
Jacob Hecksher-SørensenVibraint ApS, Frederiksberg, Denmark.
Meaghan C CreedDepartment of Psychiatry, Washington University in St. Louis, St. Louis MO, USA.ORCID 0000-0002-9658-2601
Alexxai V KravitzDepartment of Psychiatry, Washington University in St. Louis, St. Louis MO, USA.ORCID 0000-0001-5983-0218

Funding

Dopaminergic control of obesity in miceR01DK136810 · NIDDK · WASHINGTON UNIVERSITY · PI Alexxai V Kravitz · 2023 to 2026
$2.1M
Dissecting the role of ventral pallidal projections to nucleus accumbens in reward processingR01DA049924 · NIDA · WASHINGTON UNIVERSITY · PI CREED, MEAGHAN C · 2020 to 2024
$2.0M
Accumbal adaptations that contribute to weight regain after weight lossR01DK138131 · NIDDK · WASHINGTON UNIVERSITY · PI Alexxai V Kravitz · 2024 to 2026
$1.5M
Interrogating Ventral Pallidal Circuits as a Therapeutic Target for ObesityF31DK138755 · NIDDK · WASHINGTON UNIVERSITY · PI JUSTIN G WANG · 2024 to 2026
$108k
NIDA NIH HHS R01 DA049924NIDDK NIH HHS F31 DK138755NIDDK NIH HHS R01 DK136810NIDDK NIH HHS R01 DK138131
6 · The paper itself

Abstract

Food intake is governed by two interacting drives. The homeostatic hunger drive regulates food intake to fulfill caloric needs while the hedonic drive promotes intake of palatable foods outside of caloric need. It is unclear which neural substrates can control the hedonic drive and thereby reduce overeating of palatable foods and associated obesity. Here, we show that ventral pallidal GABAergic neurons (VP

Indexed as

arcuatediet-induced obesityGABAergic neuronshedonic feedingmotivationventral pallidum

Identifiers

PMID42395477
PMCPMC13320888

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.