Evidence map›Paper›PMID 42395489›Full record

ArticlebioRxiv : the preprint server for biology2026

Inhibition of RNA splicing is a novel therapeutic strategy for disruption of nuclear replicating viruses.

Lorenzo Serra, Claire M O'Brien, Molly R Patterson, Clayton J Otter, Alison Yu, Reyes W Acosta, Daniel T Claiborne, Susan R Weiss, Alexander M Price

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lorenzo SerraGenome Regulation and Cell Signaling, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, United States.
Claire M O'BrienGenome Regulation and Cell Signaling, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, United States.
Molly R PattersonGenome Regulation and Cell Signaling, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, United States.
Clayton J OtterDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Alison YuGenome Regulation and Cell Signaling, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, United States.
Reyes W AcostaGenome Regulation and Cell Signaling, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, United States.
Daniel T ClaiborneGenome Regulation and Cell Signaling, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, United States.
Susan R WeissDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Alexander M PriceGenome Regulation and Cell Signaling, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, United States.ORCID 0000-0003-4654-4604

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9M
TRAINING PROGRAM IN BASIC CANCER RESEARCHT32CA009171 · NCI · WISTAR INSTITUTE · PI Alessandro Gardini · 1985 to 2026
$15.3M
TRAINING IN HIV PATHOGENESIST32AI007632 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, James L. Riley · 2000 to 2026
$10.6M
MERS coronavirus: antagonism of double-stranded RNA induced host response by accessory proteinsR01AI140442 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Susan R Weiss · 2018 to 2026
$5.1M
Human coronavirus infection of the nasal epitheliumR01AI169537 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Noam A Cohen, Susan R Weiss · 2022 to 2026
$3.7M
Developing potent HIV-specific CAR T cells through optimizing antigen sensitivityR01AI186810 · NIAID · WISTAR INSTITUTE · PI Daniel Thomas Claiborne · 2024 to 2026
$1.7M
dsRNA production and sensing during DNA virus infectionR00AI159049 · NIAID · WISTAR INSTITUTE · PI PRICE, ALEXANDER MATTHEW · 2023 to 2024
$498k
NCI NIH HHS P30 CA010815NCI NIH HHS T32 CA009171NIAID NIH HHS R00 AI159049NIAID NIH HHS R01 AI140442NIAID NIH HHS R01 AI169537NIAID NIH HHS R01 AI186810NIAID NIH HHS T32 AI007632
6 · The paper itself

Abstract

RNA splicing is a fundamental feature of eukaryotic gene expression that is co-opted by many nuclear-replicating viruses to produce viral transcripts. Recent clinical development of spliceosome-targeting therapeutics has demonstrated that splicing can be safely modulated

Identifiers

PMID42395489
PMCPMC13320946

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.