Evidence map›Paper›PMID 42395501›Full record

ArticlebioRxiv : the preprint server for biology2026

Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models.

M Belal, T Perez-Rosello, E B Guven, S Kocaturk, Z Xie, E Ilijic, T Tkatch, J Li, W Dauer, M Assous and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

M BelalDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-8778-0617
T Perez-RoselloDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0009-0007-8952-2276
E B GuvenMolecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.ORCID 0000-0002-9634-0485
S KocaturkSchool of Biosciences, Cardiff University, Cardiff, UK.ORCID 0000-0002-0248-4825
Z XieDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-8348-4455
E IlijicDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-7112-4401
T TkatchDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-6626-7435
J LiDepartment of Internal Medicine, University of Michigan Medical School. Ann Arbor, MI, USA.
W DauerPeter O'Donnell Jr. Brain Institute, Departments of Neurology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1775-7504
M AssousSchool of Biosciences, Cardiff University, Cardiff, UK.ORCID 0000-0001-6039-816X
J M TepperMolecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.ORCID 0000-0002-8643-4082
V R J ClarkeDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-6154-6555
D J SurmeierDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-6376-5225

Funding

DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUMR37NS034696 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DALTON JAMES SURMEIER · 2001 to 2026
$7.3M
NINDS NIH HHS R37 NS034696
6 · The paper itself

Abstract

Parkinson's disease (PD) is known to alter the intrinsic properties of striatal cholinergic interneurons (ChIs). However, how PD shapes ChI control of intrastriatal GABAergic circuits regulating principal spiny projection neurons (SPNs) is unknown. To fill this gap, striatal circuits in healthy and parkinsonian mice were interrogated. In

Indexed as

computationaldendritedopamineinterneuronnicotinicstriatumsynapse

Identifiers

PMID42395501
PMCPMC13320840

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.