ArticleFood & nutrition research2026
Maternal cafeteria diet and methyl donor supplementation modulate gut microbiota and anxiety-like behavior in male offspring.
Article in Food & nutrition research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal cafeteria diet and methyl donor supplementation modulate gut microbiota and behavioral outcomes in male offspring. Background: Maternal hypercaloric diets rich in saturated fats and refined sugars are associated with metabolic alterations, gut microbiota dysbiosis, and behavioral disturbances in offspring. Methyl donor supplementation has been proposed as a potential strategy to modulate these effects. Objective: To evaluate the effect of maternal cafeteria diet consumption and methyl donor supplementation on gut microbiota composition and behavioral outcomes in male offspring in a murine model. Design: Female C57BL/6 mice were assigned to four dietary groups: control, cafeteria diet, control supplemented with methyl donors, and cafeteria diet supplemented with methyl donors. Diet exposure occurred during pre-gestation, gestation, and lactation. Male offspring were evaluated at 8 weeks of age using behavioral tests and gut microbiota analysis based on 16S rRNA gene sequencing. Associations between gut microbiota and behavioral parameters were evaluated using adjusted linear regression models controlling for maternal diet and methyl donor supplementation. Results: Offspring from cafeteria-fed dams supplemented with methyl donors showed higher microbial diversity compared to the non-supplemented cafeteria group. Cafeteria diet increased the abundance of Discussion: Maternal cafeteria diet modulated offspring gut microbiota composition and was associated with anxiety-related behavioral parameters. Methyl donor supplementation showed differential effects depending on maternal dietary context, reducing specific bacterial taxa associated with inflammatory and metabolic alterations. Conclusions: Maternal methyl donor supplementation attenuated specific microbiota alterations induced by cafeteria diets and was associated with microbiota-behavior relationships related to anxiety-like responses in offspring.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.