Milk fat globule membrane in early-life nutrition: composition, production, and biological effects on infant immune maturation, intestinal development, neurocognitive function, and growth.

Emine Kocyigit, Elif Çelik, Özge Cemali, Oya Berkay Karaca, Bence Raposa, Duygu Ağagündüz

Abstract readReview

In one paragraph

Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emine KocyigitFaculty of Health Sciences, Department of Nutrition and Dietetics, Ordu University, Ordu, Türkiye.

Elif ÇelikFaculty of Health Sciences, Department of Nutrition and Dietetics, Süleyman Demirel University, Isparta, Türkiye.

Özge CemaliFaculty of Health Sciences, Department of Nutrition and Dietetics, Trakya University, Edirne, Türkiye.

Oya Berkay KaracaFaculty of Fine Arts, Department of Gastronomy and Culinary Arts, Cukurova University, Adana, Türkiye.

Bence RaposaInstitute of Basics of Health Sciences, Midwifery and Health Visiting, Faculty of Health Sciences, University of Pécs, Pécs, Hungary.

Duygu AğagündüzFaculty of Health Sciences, Department of Nutrition and Dietetics, Gazi University, Ankara, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The milk fat globule membrane (MFGM) is a trilayered structure encasing fat globules in mammalian milk, primarily composed of phospholipids, glycoproteins, and bioactive molecules. Recent research indicates that MFGM plays a fundamental role in early-life health, particularly through its effects on gut microbiota development and immune system maturation. In the initial months of life, the infant's gut microbiome undergoes rapid colonization, essential for immunological tolerance, metabolic programming, and pathogen defense. Numerous studies have shown that MFGM components, including sphingomyelin, gangliosides, and glycoproteins, exhibit prebiotic-like effects by facilitating the proliferation of beneficial bacteria, such as

Indexed as

growthhealthinfantmicrobiomemilk fat globule membraneneurocognitive

Identifiers

PMID42395632

DOI10.3389/fnut.2026.1851487

PMCPMC13323632

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.