Evidence map›Paper›PMID 42395675›Full record

ArticleWorld journal of nephrology2026

Gut microbiota in a Saudi population with chronic kidney disease.

Afnan A Almuhanna, Chittibabu Vatte, Qian Guo, Tamer S Elsalamouni, Fahd A Al-Muhanna, Ameen M Aboalrihy, Hassan A Alhabib, Mohammed F Almomen, Rudaynah A Alali, Alawi H Habara and 7 more

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Article in World journal of nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Afnan A AlmuhannaDepartment of Radiology, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Chittibabu VatteDepartment of Clinical Biochemistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Qian GuoDivision of Transplantation, Department of Surgery, New York University Langone Health, New York, NY 10016, United States.
Tamer S ElsalamouniDepartment of Internal Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Fahd A Al-MuhannaDepartment of Internal Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Ameen M AboalrihyDepartment of Internal Medicine, Qatif Health Network Eastern Province, Qatif 32654, Saudi Arabia.
Hassan A AlhabibDepartment of Internal Medicine, Jubail General Hospital, Jubail 35514, Saudi Arabia.
Mohammed F AlmomenDepartment of Internal Medicine, King Fahd Hospital, Alahssa 31982, Saudi Arabia.
Rudaynah A AlaliDepartment of Internal Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Alawi H HabaraDepartment of Clinical Biochemistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Mohammed A AlrubaishDepartment of Ophthalmology, King Fahd Hospital of University, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Kaltham M AlfalahDepartment of Internal Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Cyril CyrusDepartment of Clinical Biochemistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Ibrahiem Saeed Abdul-RahmanDepartment of Internal Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Brendan J KeatingDivision of Transplantation, Department of Surgery, New York University Langone Health, New York, NY 10016, United States.
Amein K Al-AliDepartment of Clinical Biochemistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia. aalali@iau.edu.sa.
Chan WangDivision of Biostatistics, Department of Population Health, New York University Langone Health, New York, NY 10061, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe gut microbiota (GM) plays an important role in chronic kidney disease (CKD) progression, and dialysis modalities can differentially impact the GM composition and function. There is also limited information on the GM in Arab populations.

aimTo investigate the distinct microbial profiles and functional alterations associated with hemodialysis (HD) and peritoneal dialysis (PD) in a Saudi Arabian cohort.

methodsWe performed whole-genome metagenomic sequencing on fecal samples from 189 participants (controls and CKD, HD, and PD patients).

resultsWe detected distinct microbial profiles across all patient groups compared with that of the controls. Microbial risk scores derived from differentially abundant taxa accurately distinguished CKD, PD, and HD patients from controls, with area under the curves exceeding 0.9. Compared with HD patients, PD patients exhibited reduced species richness, an increased abundance of opportunistic pathogens (particularly

conclusionThe findings of this study highlight the potential of the microbial profile as a robust biomarker for CKD classification and underscore the differential impacts of different dialysis modalities.

Indexed as

Chronic kidney diseaseHemodialysisMicrobiotaPeritoneal dialysisSaudi

Identifiers

PMID42395675
PMCPMC13324665

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.