ArticleACS omega2026
Evaluation of the Stratum Corneum Retention Abilities of Monoterpenes and Sesquiterpenes: Strategy for the Discovery of Potent Penetration Enhancers.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
11 authors.
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Abstract
Predicting skin penetration enhancers (PEs) from numerous terpenes is of interest for the development of the transdermal drug delivery system (TDDS) and remains a great challenge. In this study, the stratum corneum (SC) retention abilities of 3 sesquiterpenes and 3 monoterpenes from Alpiniae Officinarum Rhizoma were compared. The sesquiterpenes included caryophyllene oxide (CPO), δ-cadinene, and β-caryophyllene, while the monoterpenes contained 4-terpineol, β-pinene, and 1,8-cineole. Long-chain sesquiterpenes showed much higher SC-retention abilities than short-chain monoterpenes. The SC-retention abilities of terpenes were directly correlated with their disturbance effects on skin-barrier function (
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