Evidence map›Paper›PMID 42396136›Full record

ArticleFrontiers in medicine2026

Concordant ETV6::RUNX1-positive acute lymphoblastic leukemia in monozygotic twins: a case report and review of the literature.

Xiaohua Li, Cuicui Wang, Jianchang Li, Chaoyue Liu, Weimei Sun, Yanjun Zhang, Jian Shi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaohua Li *Pediatric Hematology and Endocrinology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Cuicui Wang *Pediatric Hematology and Endocrinology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Jianchang LiPediatric Hematology and Endocrinology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Chaoyue LiuPediatric Hematology and Endocrinology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Weimei SunPediatric Hematology and Endocrinology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Yanjun ZhangPediatric Hematology and Endocrinology, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Jian ShiDepartment of Hepatobiliary and Pancreatic Surgery, Binzhou Medical University Hospital, Binzhou, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patient A, a 1-year-and-6-month-old male, was admitted due to "fever for 2 days". Patient B, a 1-year-and-9-month-old male, the monozygotic twin brother of Patient A, was admitted due to "fever for 1 day and abnormal blood findings detected 1 h prior to admission". The twin siblings underwent bone marrow examinations and were consecutively diagnosed with acute lymphoblastic leukemia, both testing positive for the ETV6::RUNX1 fusion gene. They received chemotherapy according to the CCLG-ALL-2018 protocol for 2 years, and both achieved complete remission. Since the completion of treatment, they have remained in continuous complete remission for over 2 years of follow-up. This case report provides additional clinical evidence supporting "the in utero origin" and "two-hit" hypotheses in pediatric ALL.

Indexed as

acute lymphoblastic leukemiaETV6::RUNX1identical twinsin utero origintwo-hit

Identifiers

PMID42396136
PMCPMC13322914

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.