Evidence map›Paper›PMID 42396235›Full record

ArticleJournal of intensive medicine2026

Impact of different extracorporeal blood purification strategies during continuous renal replacement therapy in septic shock patients.

Pedja Kovacevic, Nikolina Spiric, Katarina Vucicevic, Sasa Dragic, Danica Momcicevic, Biljana Zlojutro, Milka Jandric, Tijana Kovacevic, Jihad Mallat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intensive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pedja KovacevicUniversity Clinical Centre of the Republic of Srpska, Medical Intensive Care Unit, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina.
Nikolina SpiricDepartment of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Katarina VucicevicDepartment of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Sasa DragicUniversity Clinical Centre of the Republic of Srpska, Medical Intensive Care Unit, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina.
Danica MomcicevicUniversity Clinical Centre of the Republic of Srpska, Medical Intensive Care Unit, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina.
Biljana ZlojutroUniversity Clinical Centre of the Republic of Srpska, Medical Intensive Care Unit, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina.
Milka JandricUniversity Clinical Centre of the Republic of Srpska, Medical Intensive Care Unit, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina.
Tijana KovacevicFaculty of Medicine, University of Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina.
Jihad MallatFaculty of Medicine, University of Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Septic shock with acute kidney injury is associated with high mortality. Hemoadsorption methods such as CytoSorb in conjunction with standard continuous renal replacement therapy (CRRT) and oXiris-based CRRT are increasingly used; however, comparative data are scarce. This study assessed the effects of both filters on vasopressor-free days and key clinical outcomes in septic shock. Methods: This retrospective single-center cohort included adults with septic shock treated with CytoSorb in conjunction with CRRT or oXiris-based CRRT between 1st January 2023 and 31st December 2024. The primary endpoint was vasopressor-free days to day 28, with secondary outcomes including Sequential Organ Failure Assessment (SOFA) score, lactate levels, norepinephrine equivalent dose (NEED), mean arterial pressure, ventilator-free days, intensive care unit (ICU) length of stay, and mortality. Results: A total of 97 patients were included in the analysis. (CytoSorb: Conclusions: CytoSorb in addition with CRRT and oXiris-based CRRT demonstrated similar hemodynamic and clinical outcomes. Larger prospective studies are needed to define the optimal role of extracorporeal CRRT-based blood purification in septic shock.

Indexed as

Continuous renal replacement therapyExtracorporeal blood purificationHemoadsorptionIntensive care unitSeptic shockTreatment outcome

Identifiers

PMID42396235
PMCPMC13323539

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.