ArticlePeerJ2026
Relationship between mental disorders and non-traumatic cerebral hemorrhage: cross-sectional analysis and mendelian randomization.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Background: The causality between mental disorders and spontaneous non-traumatic cerebral hemorrhage (NCH) has not been sufficiently explored. This study aims to investigate the associations of a broad spectrum of 16 mental disorders with NCH through Mendelian randomization (MR) analysis and to assess the association in a real-world study. Methods: Univariate analysis and mediational MR analysis were employed to investigate the potential association between mental disorders and NCH. Genetic instruments associated with mental disorders were identified through a genome-wide association study (GWAS) using the FinnGen database of European populations. Furthermore, the MR results were corroborated based on the real population (MIMIC-IV database). The correlation between mental disorders and the risk of NCH was examined using logistic regression models, which progressively added confounding factors for adjustments. Results: Univariate MR analysis showed that genetically predicted dementia was significantly associated with NCH (OR = 1.090, 95% CI [1.049-1.133], Conclusions: Results of both MR analyses and observational studies showed that dementia was associated with the risk of NCH. Furthermore, reverse MR analysis revealed no causal effect of NCH on dementia.
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