Evidence mapPaperPMID 42396480Full record

ArticleResearch square2026

TMEM119+ microglia MHC class I restricted antigen presentation impacts CD8 T cell memory, effector status, and blood-brain barrier disruption during neurotropic virus infection.

Marina Seady, Mark A Maynes, Javonte S Thelwell, Fang Jin, Michael J Hansen, Hadley E Jensen, Ryann K Witter, Carley A Owens, Asma Hassani, Cody L Lewis and 2 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marina SeadyMayo Clinic Department of Immunology, Rochester, MN.
Mark A MaynesMayo Clinic Department of Immunology, Rochester, MN.
Javonte S ThelwellGraduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN.
Fang JinMayo Clinic Department of Immunology, Rochester, MN.
Michael J HansenMayo Clinic Department of Immunology, Rochester, MN.
Hadley E JensenMayo Clinic Department of Immunology, Rochester, MN.ORCID 0009-0000-4651-8807
Ryann K WitterMayo Clinic Department of Immunology, Rochester, MN.
Carley A OwensMayo Clinic Department of Immunology, Rochester, MN.
Asma HassaniMayo Clinic Department of Immunology, Rochester, MN.ORCID 0000-0001-7792-2140
Cody L LewisMayo Clinic Department of Immunology, Rochester, MN.
Michael D ForstonMayo Clinic Department of Immunology, Rochester, MN.ORCID 0000-0001-7759-225X
Aaron J JohnsonMayo Clinic Department of Immunology, Rochester, MN.

Funding

CD8 T cell mediated disruption of Blood Brain Barrier Tight JunctionsR01NS103212 · MAYO CLINIC ROCHESTER · 2025 to 2025
$591k
Defining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and TauopathyR01NS122174 · MAYO CLINIC ROCHESTER · 2025 to 2025
$588k
Training Program in ImmunologyT32AI170478 · MAYO CLINIC ROCHESTER · 2025 to 2025
$322k
NIAID NIH HHS T32 AI170478NINDS NIH HHS R01 NS103212NINDS NIH HHS R01 NS122174
6 · The paper itself

Abstract

The impact of microglia antigen presentation on CNS infiltrating CD8 T cells responses during neurotropic virus infection remains undefined. Using Theiler's murine encephalomyelitis virus (TMEV) infection of neurons as a model system, we generated H-2K

Indexed as

antigen presentationCD8 T cellsMHC class IMicrogliaperforin

Identifiers

PMID42396480
PMCPMC13321286

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.