Evidence map›Paper›PMID 42396509›Full record

ArticleResearch square2026

Striosomal ghrelin receptor activity controls reward-cost integration.

Alexis A Salcido, Neftali F Reyes, Andrea Y Macias, Serina A Batson, Dirk W Beck, Kenichiro Negishi, Cory N Heaton, Atanu Giri, Luis D Davila, Raquel J Ibáñez Alcalá and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Alexis A SalcidoDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.ORCID 0000-0002-1063-5902
Neftali F ReyesDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Andrea Y MaciasDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Serina A BatsonDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Dirk W BeckComputational Science Program, University of Texas at El Paso, El Paso, TX, USA.
Kenichiro NegishiNeurobiology of Relapse Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.ORCID 0000-0001-8283-9202
Cory N HeatonDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.ORCID 0009-0000-0251-1371
Atanu GiriComputational Science Program, University of Texas at El Paso, El Paso, TX, USA.
Luis D DavilaComputational Science Program, University of Texas at El Paso, El Paso, TX, USA.
Raquel J Ibáñez AlcaláDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.ORCID 0009-0008-0440-9192
Lara I RakocevicComputational Science Program, University of Texas at El Paso, El Paso, TX, USA.
Hui-Ling WangNeurobiology of Relapse Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.
Eduardo MontañezDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Celine N OrozcoDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Mia MaestasDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Alma C Moreno-DominguezDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Carlos GranilloDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Ian R WickershamMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-0389-5324
Yavin ShahamNeurobiology of Relapse Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA.ORCID 0000-0002-8242-3319
Travis M MoschakDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.
Ki A GoosensDepartment of Psychiatry, Department of Pharmacological Sciences; Icahn School of Medicine at Mount Sinai, New York, NY, United States.ORCID 0000-0002-5246-2261
Alexander FriedmanDepartment of Biological Sciences, University of Texas at El Paso, El Paso, TX, USA.ORCID 0009-0006-0882-5324

Funding

Build-out of an Imaging and Behavioral Neuroscience Facility for Hispanic Health Disparities at UTEPC06OD032074 · OD · UNIVERSITY OF TEXAS EL PASO · PI KENNEY, MICHAEL J · 2021 to 2021
$5.1M
A2: Striosomal models of drug use and costR01DA058653 · NIDA · UNIVERSITY OF TEXAS EL PASO · PI Alexander Friedman, Travis M Moschak · 2024 to 2026
$1.7M
Ghrelin receptor and striosomal interactions in stress-induced decision-makingR01MH142540 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Alexander Friedman, Ki Ann Goosens · 2026 to 2026
$828k
NIDA NIH HHS R01 DA058653NIH HHS C06 OD032074NIMH NIH HHS R01 MH142540
6 · The paper itself

Abstract

Growth hormone secretagogue receptors (GHSRs) modulate reward and cost processing separately, but their role in conflict-based decision-making is unclear. We observed dose-dependent effects of the GHSR agonist ibutamoren (IBU) on rat decision-making performance. Moderate, but not low or high doses, increased cost sensitivity selectively in conflict paradigms. We observed dense GHSR expression in dorsomedial striosomes, a region critical for conflict decision-making. Moderate GHSR activation increased neuronal activity in dorsomedial striosomes that project to lateral habenula (LHb) and enhanced inactivation of dopaminergic neurons in the substantia nigra pars compacta (daSNc). Chemogenetic manipulation of dorsomedial striosomes activity confirmed their causal influence on both GHSR-mediated increases in cost-sensitivity and circuit activity in LHb and daSNc. Our results identify a novel circuit mechanism linking endocrine activity with conflict decision-making.

Identifiers

PMID42396509
PMCPMC13321320

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.