ArticleResearch square2026
Impact of Parenchymal Hemorrhage on Internal Carotid Artery Wall Shear Stress in Post-Traumatic Vasospasm: A Dynamic Helical CTA Study.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Background: Post-traumatic cerebral vasospasm (CVS) significantly worsens outcomes in moderate-to-severe traumatic brain injury (msTBI). While wall shear stress (WSS) modulates endothelial function, its state in post-traumatic CVS remains poorly understood. We aimed to assess supraclinoid internal carotid artery (ICA) WSS in msTBI patients with and without non-surgical parenchymal hemorrhage. Methods: This retrospective cohort study (2013-2024) included 85 adults with msTBI and angiographic CVS. Patients were divided into Group 1 (Marshall II-III, no hematoma; n=43) and Group 2 (Marshall IV, non-surgical parenchymal hemorrhage; n=42). Dynamic helical CT angiography (DHCTA) and Doppler ultrasound were performed 2-5 days post-injury. WSS in the ICA C7 segment was calculated using a Poiseuille-based formula incorporating mean CBFV and vessel radius. Results: ICA WSS significantly exceeded the reference range (0.82 ± 0.08 Pa) in both groups (p<0.001). In Group 2, WSS was significantly higher than in Group 1 (p<0.0001). Specifically, Group 2 ipsilateral WSS (64.4 ± 9.8 Pa) was significantly higher than both the contralateral side (49.3 ± 8.3 Pa; p=0.021) and the Group 1 mean (33.2 ± 7.5 Pa; p<0.0001). No significant age-WSS correlation was observed (p=0.72). Group 2 exhibited a trend toward worse clinical outcomes (GOS), though only moderate disability (GOS 4) showed a significant difference (p<0.05). Conclusions: Post-traumatic CVS in msTBI is associated with markedly elevated ICA WSS. The presence of parenchymal hemorrhage further amplifies this hemodynamic stress, potentially contributing to non-physiological microcirculatory remodeling. These findings suggest WSS could serve as a biomarker for secondary brain injury risk, necessitating individualized surgical and medical management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.