Evidence map›Paper›PMID 42396647›Full record

ReviewInternational journal of molecular medicine2026

Role of ZEB1 in angiogenesis and therapeutic potential (Review).

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruoxin Ren *Department of Ophthalmology, The Third People's Hospital Affiliated to Dalian University of Technology, Dalian Eye Hospital, Liaoning Provincial Key Laboratory of Cornea and Ocular Surface Diseases, Liaoning Provincial Optometry Technology Engineering Research Center, Liaoning Branch of the National Clinical Research Center for Eye Diseases, Dalian, Liaoning 116033, P.R. China.
Chunxiao Yan *Department of Ophthalmology, The Third People's Hospital Affiliated to Dalian University of Technology, Dalian Eye Hospital, Liaoning Provincial Key Laboratory of Cornea and Ocular Surface Diseases, Liaoning Provincial Optometry Technology Engineering Research Center, Liaoning Branch of the National Clinical Research Center for Eye Diseases, Dalian, Liaoning 116033, P.R. China.
Yao XiangDepartment of Ophthalmology, The Third People's Hospital Affiliated to Dalian University of Technology, Dalian Eye Hospital, Liaoning Provincial Key Laboratory of Cornea and Ocular Surface Diseases, Liaoning Provincial Optometry Technology Engineering Research Center, Liaoning Branch of the National Clinical Research Center for Eye Diseases, Dalian, Liaoning 116033, P.R. China.
Lin JinDepartment of Ophthalmology, The Third People's Hospital Affiliated to Dalian University of Technology, Dalian Eye Hospital, Liaoning Provincial Key Laboratory of Cornea and Ocular Surface Diseases, Liaoning Provincial Optometry Technology Engineering Research Center, Liaoning Branch of the National Clinical Research Center for Eye Diseases, Dalian, Liaoning 116033, P.R. China.
Fang ChengDepartment of Pharmaceutical Sciences, State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning 116081, P.R. China.
Lijun ZhangDepartment of Ophthalmology, The Third People's Hospital Affiliated to Dalian University of Technology, Dalian Eye Hospital, Liaoning Provincial Key Laboratory of Cornea and Ocular Surface Diseases, Liaoning Provincial Optometry Technology Engineering Research Center, Liaoning Branch of the National Clinical Research Center for Eye Diseases, Dalian, Liaoning 116033, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc finger E‑box binding homeobox 1 (ZEB1), a key transcription factor governing epithelial‑mesenchymal transition, plays indispensable roles in embryonic development, neural differentiation and a wide range of pathological processes. Emerging evidence has revealed that ZEB1 exerts multifaceted and context‑dependent functions in angiogenesis. Under physiological conditions, ZEB1 contributes to the regulation of vascular development and endothelial homeostasis, whereas in pathological settings it promotes aberrant neovascularization through diverse molecular mechanisms. In the present review, the structural characteristics, biological functions and regulatory mechanisms of ZEB1 were systematically summarized, with a particular focus on recent advances regarding its roles in both physiological and pathological angiogenesis. Furthermore, the therapeutic potential of targeting ZEB1 in vascular diseases was discussed and future research directions that may facilitate the development of novel strategies for the prevention and treatment of angiogenesis‑related disorders were highlighted.

Indexed as

AngiogenesisNeovascularization, PathologicNeovascularization, PhysiologicZinc Finger E-box-Binding Homeobox 1AnimalsEpithelial-Mesenchymal TransitionHumansZinc Finger E-box-Binding Homeobox 1angiogenesisEMTtherapeuticZEB1

Identifiers

PMID42396647
PMCPMC13336624

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.