Observational studyJournal of the American Heart Association2026
Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima-Media Thickness as a Window Into Cardiac Remodeling.
Observational study in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
backgroundCarotid intima-media thickness (cIMT) is a noninvasive marker of subclinical atherosclerosis linked to future cardiovascular disease (CVD). However, its relationship with early cardiac remodeling and shared genetic basis with cardiovascular disease remain poorly understood. We investigated the phenotypic and genetic associations between cIMT, aortic and cardiac traits, and cardiovascular disease in the UK Biobank, a large population-based cohort with comprehensive imaging and genetics.
methodsWe analyzed 46 102 participants with carotid ultrasound and cardiac magnetic resonance imaging, excluding those with prevalent heart failure, atrial fibrillation, or stroke. Multivariable linear and Cox regression models assessed associations between common cIMT, aortic and cardiac traits, and incident cardiovascular disease, with effect estimates expressed per 1 SD increase in cIMT. Genetic correlations and pathway enrichment analyses were performed using genome-wide association studies summary statistics.
resultsHigher cIMT was associated with aortic enlargement, left ventricular hypertrophy, and greater chamber volumes, alongside reduced biatrial ejection fractions (all
conclusionIncreased cIMT is associated with systemic aortic and cardiac remodeling and decreased dilated cardiomyopathy risk. Integrative genetic analyses revealed shared heritable mechanisms, highlighting cIMT as a marker of early cardiovascular structural change, potentially bridging vascular and cardiac disease processes.
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