ArticleJournal of the American Heart Association2026
Associations of Accelerometer-Derived "Weekend Warrior" Physical Activity Pattern With Incident First Cardiometabolic Disease and Cardiometabolic Multimorbidity in Individuals With Hypertension.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo examine associations between accelerometer-derived "weekend warrior" (WW) physical activity pattern (most moderate-to-vigorous-intensity physical activity in 1-2 days) versus moderate-to-vigorous-intensity physical activity spread more evenly with risks of incident first cardiometabolic disease (FCMD) and cardiometabolic multimorbidity (CMM) among hypertension participants.
methodsUK Biobank participants with hypertension (n=26891) provided a full-week of accelerometer-derived physical activity data between 2013 and 2015, processed using GGIR and a machine-learning classifier. CMM was defined as the occurrence of at least 2 of type 2 diabetes, ischemic heart disease, and stroke. Three activity patterns (WW, regular, and inactive) were compared across multiple thresholds and definitions of active WW, with significance corrected for multiple comparisons at a false discovery rate of 0.05.
resultsOver 7.5 years median follow-up, 2718 individuals developed FCMD and 219 developed CMM. Using the definition of WW as guideline-based and ≥50% of total moderate-to-vigorous-intensity physical activity over 1 to 2 days via GGIR, we observed similarly lower risks of incident FCMD (WW versus inactive: hazard ratio [HR], 0.75 [95% CI, 0.69-0.82],
conclusionsIncreased activity, even when concentrated within 1 to 2 days/week may reduce cardiometabolic disease risk in individuals with hypertension.
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