Evidence map›Paper›PMID 42397442›Full record

Trial reportEuropean journal of nutrition2026

Interesterified fats rich in palmitic and stearic acids have comparable effects on selected inflammatory related biomarkers.

Yen Teng Ng, Phooi Tee Voon, Tony Kock Wai Ng, Verna Kar Mun Lee, Miskandar Mat Sahri, Norhaizan Mohd Esa

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02192047 (Chronic Effects of Natural Palm-based Margarine and Interesterified Palm- and Soy-based Margarine on Insulin Sensitivity and Selected Markers of Cardiovascular Diseases), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02192047 nacompletednot on this map

Chronic Effects of Natural Palm-based Margarine and Interesterified Palm- and Soy-based Margarine on Insulin Sensitivity and Selected Markers of Cardiovascular Diseases (CVD)

TypeinterventionalSponsorMalaysia Palm Oil BoardRan2012 to 2014Enrolled85ConditionsOverweightArmsPalm Olein, IE Palm olein, IE soybean oil-based
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yen Teng NgNutrition Unit, Division of Product Development and Advisory Services, Malaysian Palm Oil Board (MPOB), Kajang, Selangor, Malaysia.
Phooi Tee VoonNutrition Unit, Division of Product Development and Advisory Services, Malaysian Palm Oil Board (MPOB), Kajang, Selangor, Malaysia. vptee@mpob.gov.my.
Tony Kock Wai NgDepartment of Allied Health Sciences, Faculty of Science, Universiti Tunku Abdul Rahman (UTAR), Perak, Malaysia.
Verna Kar Mun LeeDepartment of Family Medicine, School of Medicine, IMU University, Kuala Lumpur, Malaysia.
Miskandar Mat Sahri, Bandar Baru Bangi, Selangor, Malaysia.
Norhaizan Mohd EsaDepartment of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveTrans fatty acids (TFA), a by-product of partial hydrogenation, have been proven to contribute significant adverse effects on human health. Interesterification has been used as an alternative to hardening edible oils instead of partial hydrogenation. There are limited reports of the impacts of interesterified fat consumption on inflammatory biomarkers. We compared the effects of chemically interesterified fats rich in palmitic (CIEPO) and stearic acid (CIEBlend) with native palm olein (POo) diets on selected inflammatory related biomarkers of 90 healthy adults.

methodsWe used a double-blind, parallel feeding intervention trial using 50 g of each test fat in the form of margarine, separately incorporated into two servings of snacks for breakfast and afternoon tea daily for eight weeks. Blood samples were collected at baseline, zero-, sixth- and eighth-week.

resultsPOo-, CIEPO- and CIEBlend-diets produce no significant difference in the serum levels of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), visfatin and high-sensitivity C-reactive protein (hsCRP).

conclusionsThe finding suggests that the long-term effects of these three fats on these selected inflammatory related biomarkers are similar. Trial registration https://clinicaltrials.gov/ , NCT02192047, 2014-07-15.

Indexed as

Dietary FatsInflammationPalmitic AcidStearic AcidsAdultBiomarkersC-Reactive ProteinDouble-Blind MethodFemaleHumansInterleukin-6MaleMargarineMiddle AgedPalm OilTrans Fatty AcidsBiomarkersC-Reactive ProteinDietary FatsInterleukin-6MargarinePalmitic AcidPalm Oilstearic acidStearic AcidsTrans Fatty AcidsTumor Necrosis Factor-alphaHuman feeding trialInflammatory markersInteresterified fatPalm-basedTFA free-margarine

Identifiers

PMID42397442

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.