Evidence map›Paper›PMID 42397496›Full record

ArticleClinical journal of gastroenterology2026

PTEN negative adenocarcinoma developed in a gastric hamartoma polyp of a Cowden syndrome patient.

Jumpei Suzuki, Bunichiro Kato, Hiro-O Matsushita, Kenjiro Yoshikawa, Haruka Yorozu, Takeya Edagawa, Hiroki Koshiishi, Takuo Tokairin, Masayuki Yoshida, Katsuhiko Enomoto

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In one paragraph

Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jumpei SuzukiClinical Training Center, Akita Red Cross Hospital, Akita, Japan.
Bunichiro KatoDepartment of Gastroenterology, Akita Red Cross Hospital, Akita, Japan. bunichiro_kato@mail.toyota.co.jp.ORCID http://orcid.org/0009-0001-5881-9268
Hiro-O MatsushitaDepartment of Gastroenterology, Akita Red Cross Hospital, Akita, Japan.
Kenjiro YoshikawaDepartment of Gastroenterology, Akita Red Cross Hospital, Akita, Japan.
Haruka YorozuDepartment of Gastroenterology, Akita Red Cross Hospital, Akita, Japan.
Takeya EdagawaDepartment of Gastroenterology, Akita Red Cross Hospital, Akita, Japan.
Hiroki KoshiishiDepartment of Gastroenterology, Akita Red Cross Hospital, Akita, Japan.
Takuo TokairinDepartment of Pathology, Akita Red Cross Hospital, Akita, Japan.
Masayuki YoshidaDepartment of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
Katsuhiko EnomotoDepartment of Pathology, Akita Red Cross Hospital, Akita, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cowden syndrome (CS) is an autosomal dominant genetic cancer predisposition disease caused by mutation of the germline phosphatase and tensin homolog (PTEN) gene. A 60s-year-old man who has been diagnosed as CS at our hospital 10 years ago due to his medical history of Lhermitte-Duclos disease (LDD), thyroid medullary carcinoma and gastrointestinal polyposis. He was regularly followed up by the endoscopic examination of gastrointestinal polyps at our hospital. A recent routine examination revealed a surface irregular and hemorrhagic gastric polyp at the lower body of stomach. As a biopsy report showed a high possibility of carcinoma, an endoscopic mucosal resection (EMR) was performed. Histopathological examination of the EMR specimen revealed well-differentiated tubular adenocarcinoma developed in a hamartoma polyp. Immunohistochemical staining using anti-PTEN antibody showed that PTEN expression was completely deficient in the nuclei of carcinoma cells as well as majority of hamartoma cells, whereas a part of hamartoma cells showed PTEN nuclear expression. Furthermore, we applied the specimen to gene panel analysis and confirmed pGly127Arg (c379G > A) mutation present in PTEN gene. Helicobacter pylori (H. pylori) infection in the biopsied gastric specimen and immunohistochemically high expression of p16

Indexed as

AdenocarcinomaHamartomaHamartoma Syndrome, MultiplePolypsPTEN PhosphohydrolaseStomach DiseasesStomach NeoplasmsEndoscopic Mucosal ResectionHumansMaleMiddle AgedPTEN PhosphohydrolasePTEN protein, humanCowden syndromeEndoscopic mucosal resectionGastric canserGastric hamartomatous polypPTEN loss

Identifiers

PMID42397496

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.