ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Association between probiotic prescriptions and the incidence of primary open-angle glaucoma in patients with documented dry eye.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
purposeTo examine the association between probiotic prescriptions and the risk of developing primary open-angle glaucoma (POAG).
methodsA retrospective cohort study was conducted using the TriNetX multinational database. Adults aged ≥ 40 years with a diagnosis of dry eye and no prior history of glaucoma were included. Participants were categorized into probiotic and non-probiotic groups based on prescription records. Propensity score matching (1:1) was performed to balance demographics, comorbidities, and medication use. Cox proportional hazards models estimated hazard ratios (HRs) with 95% confidence intervals (CIs), and Kaplan-Meier analyses assessed five-year cumulative incidence. Sensitivity and subgroup analyses were performed to examine robustness and consistency across clinical subgroups.
resultsAmong 15,613 matched pairs, probiotic prescriptions were associated with lower risks of POAG (HR: 0.44; 95% CI: 0.32-0.61). These associations remained consistent in sensitivity analyses and were observed across multiple subgroups stratified by age, sex, race, diabetes status, and obesity.
conclusionsProbiotic prescriptions were associated with a reduced risk of POAG in this large real-world cohort. These findings highlight the need for prospective studies to confirm causality and explore underlying mechanisms.
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42397591What Socratic holds
Registered trials
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