ArticleScience advances2026
Self-vocalizations activate the developing auditory cortex via an intracortical pathway.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The development of the sensory brain relies on early periphery-generated spontaneous neural activity and later sensory-evoked activity. To investigate activity sources in the auditory cortex (ACtx) during development, we performed in vivo imaging in neonatal mouse pups. We found self-vocalization-associated ACtx activity even before ear opening and that this activity was stronger than tone-evoked activity. Self-vocalization-associated activity also existed in deaf pups, suggesting a top-down activity source. We revealed projections from the anterior cingulate cortex (ACC) and secondary motor cortex (M2) to the ACtx and that ACC/M2 showed vocalization-driven activity correlated with ACtx activity. ACC/M2 inactivation reduced self-vocalization and ACtx activity. Thus, self-vocalizations activate the developing ACtx even before ear opening, potentially via ACC/M2 motor commands. Our results reveal a previously unidentified early ACtx activity source that can shape development.
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