Evidence map›Paper›PMID 42398926›Full record

ArticleJournal of proteome research2026

Identification of Age-Associated Circulating Proteins and Lipids in 3800 Comorbidity-Enriched Older Adults from Japan-Based Cohorts Using Olink Assays and MRM Mass Spectrometry.

Suzumi M Tokuoka, Fumie Hamano, Ayako Kobayashi, Tohru Natsume, Masaya Sugiyama, Koichi Matsuda, Yoshiya Oda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suzumi M TokuokaGraduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0051, Japan.
Fumie HamanoGraduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0051, Japan.
Ayako KobayashiGraduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0051, Japan.
Tohru NatsumeCellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, 2-3-26 Aoumi, Koto-ku, Tokyo135-0064, Japan.
Masaya SugiyamaDepartment of Viral Pathogenesis and Controls, National Institute of Global Health and Medicine, Japan Institute for Health Security, 1-7-1 Kohnodai, Ichikawa, Chiba272-8516, Japan.
Koichi MatsudaGraduate School of Frontier Sciences, The University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, Tokyo108-8639, Japan.
Yoshiya OdaGraduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo113-0051, Japan.ORCID 0000-0001-5680-6394

Funding

AMED 223fa627011AMED 23tm0624002j0001AMED 243fa627011h003AMED 24ae0121041s0104JSPS KAKENHI 21K06853Shimadzu Corporation None
6 · The paper itself

Abstract

Aging entails complex physiological changes, yet large-scale evidence among older Japanese individuals, especially those with comorbidities, remains limited. We analyzed serum and plasma samples from approximately 3800 Japanese aged 40 years and older to identify age-associated proteins and lipids, focusing on reproducibility and robustness. Chemokines CXCL9 and CCL11 and phosphatidylcholines PC 31:0 and PC 32:0 were positively associated with age across five cohorts, whereas lysophosphatidylcholines LPC-LA and LPC-AA showed negative associations. These molecular relationships were consistently reproduced across serum and plasma matrices and replicated in independent cohorts. Cross-platform consistency was confirmed between Olink Target 96 (relative NPX) and Target 48 (absolute quantification), with direct validation in Cohort 2. To our knowledge, this is the largest study to demonstrate reproducibility of age-associated molecular biomarkers in a comorbidity-enriched Japanese population. The principal contribution is technical─defining a set of robust, cross-platform, cross-matrix biomarkers of aging in older adults. Unlike previous Western studies which focused on younger or healthier populations, this work establishes reproducibility and generalizability in real-world aging. These validated biomarkers provide a valuable reference for clinical and translational research, including risk stratification and biological age assessment in comorbidity-enriched settings.

Indexed as

AgingBlood ProteinsLipidsAdultAgedAged, 80 and overBiomarkersChemokine CCL11Chemokine CXCL9Cohort StudiesComorbidityFemaleHumansJapanLysophosphatidylcholinesMaleBiomarkersBlood ProteinsCCL11 protein, humanChemokine CCL11Chemokine CXCL9CXCL9 protein, humanLipidsLysophosphatidylcholinesPhosphatidylcholinesaging biomarkersCCL11comorbidity-enriched cohortscross-matrixcross-platformCXCL9lysophosphatidylcholinesmultiomicsolder Japanese

Identifiers

PMID42398926
PMCPMC13459531

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.