Evidence map›Paper›PMID 42399244›Full record

ArticleNature communications2026

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila.

K Huang, T Miao, Y Chen, E Dantas, J Sanford, John M Asara, S J Moon, Y Hu, K Wang, M Han and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

K Huang *Department of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA, USA. Kerui_Huang@hms.harvard.edu.ORCID http://orcid.org/0000-0003-1866-8407
T Miao *Department of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0634-7377
Y ChenDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA, USA.
E DantasNYU Langone Health, New York, NY, USA.
J SanfordNYU Langone Health, New York, NY, USA.
John M AsaraDivision of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7450-2589
S J MoonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA, USA.
Y HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1494-1402
K WangDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA, USA.
M HanDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA, USA.
M GoncalvesNYU Langone Health, New York, NY, USA.ORCID http://orcid.org/0000-0002-0784-9248
N PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA, USA. perrimon@genetics.med.harvard.edu.ORCID http://orcid.org/0000-0001-7542-472X

Funding

Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
CANCAN - HarvardOT2CA278689 · NCI · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2022 to 2026
$1.1M
CANCAN ? CORNELLOT2CA278685 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GONCALVES, MARCUS DASILVA · 2022 to 2023
$657k
Cancer Research UK (CRUK) CGCATF-2021/100022NCI NIH HHS OT2 CA278685NCI NIH HHS OT2 CA278689NCI NIH HHS P01 CA120964U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1OT2 809 CA278685-01U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) 5P01CA120964-15
6 · The paper itself

Abstract

Tumors reprogram lipid metabolism in distant tissues to support their growth. In adult Drosophila, gut tumors secrete the PDGF/VEGF-like factor Pvf1, which activates the TORC1-Hnf4 pathway in hepatocyte-like oenocytes. This drives production of very long-chain fatty acids and wax esters essential for tracheal growth around the tumor. Blocking Hnf4 or the elongase mElo in oenocytes strongly suppresses tracheogenesis, tumor progression, and cachexia-like organ wasting, while extending host lifespan. The same pathway also controls tracheal development in healthy flies. Lipoprotein receptor LpR2 depletion in oenocytes rescues the observed tumor induced tracheal tracheal remodeling. This tumor-host interaction is conserved: VEGF-A induces lipid metabolism genes in human hepatocytes, and lung tumor-bearing mice show elevated hepatic Hnf4 and Elovl7. Altogether, this study reveals a non-autonomous role of the TORC1-Hnf4 axis in lipid-mediated tumor progression and identifies potential therapeutic targets for cancer-associated metabolic dysfunction.

Indexed as

HepatocytesIntestinal NeoplasmsLipid MetabolismAnimalsDrosophilaDrosophila melanogasterDrosophila ProteinsHepatocyte Nuclear Factor 4HumansMechanistic Target of Rapamycin Complex 1MiceSignal TransductionVascular Endothelial Growth Factor ADrosophila ProteinsHepatocyte Nuclear Factor 4Mechanistic Target of Rapamycin Complex 1Vascular Endothelial Growth Factor A

Identifiers

PMID42399244
PMCPMC13470496

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.