Evidence map›Paper›PMID 42399585›Full record

ArticleBiological trace element research2026

Sodium Selenite Preconditioning Reprograms Mesenchymal Stem Cell Behavior Under Inflammatory Stress to Enhance Anti-Inflammatory Macrophage Responses.

Iolanda Silva Rafael Pizzolato-Cezar, Edson Naoto Makiyama, Luis Ricardo Pizzolato-Cezar, Kalil Auzier Martins Costa, Carlos Eduardo da Silva Gonçalves, Sumara de Freitas, Renata Chaves Albuquerque, Ricardo Ambrósio Fock

Abstract read
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In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Iolanda Silva Rafael Pizzolato-CezarLaboratory of Experimental Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Lineu Prestes Avenue, 580 - Block17, São Paulo, SP, 05508-900, Brazil.
Edson Naoto MakiyamaLaboratory of Experimental Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Lineu Prestes Avenue, 580 - Block17, São Paulo, SP, 05508-900, Brazil.
Luis Ricardo Pizzolato-CezarDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.
Kalil Auzier Martins CostaLaboratory of Experimental Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Lineu Prestes Avenue, 580 - Block17, São Paulo, SP, 05508-900, Brazil.
Carlos Eduardo da Silva GonçalvesLaboratory of Experimental Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Lineu Prestes Avenue, 580 - Block17, São Paulo, SP, 05508-900, Brazil.
Sumara de FreitasLaboratory of Experimental Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Lineu Prestes Avenue, 580 - Block17, São Paulo, SP, 05508-900, Brazil.
Renata Chaves AlbuquerqueLaboratory of Experimental Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Lineu Prestes Avenue, 580 - Block17, São Paulo, SP, 05508-900, Brazil.
Ricardo Ambrósio FockLaboratory of Experimental Hematology, Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Lineu Prestes Avenue, 580 - Block17, São Paulo, SP, 05508-900, Brazil. hemato@usp.br.ORCID http://orcid.org/0000-0002-7964-5973

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation critically influences mesenchymal stem cell (MSC) behavior, affecting their survival, plasticity, and immunomodulatory functions. MSC preconditioning has emerged as a promising strategy to enhance their therapeutic potential before clinical application. Among the factors capable of modulating MSC responses, selenium has gained attention due to its role in regulating inflammatory signaling. In this study, we investigated whether high-dose sodium selenite (Na

Indexed as

Anti-Inflammatory AgentsInflammationMacrophagesMesenchymal Stem CellsSodium SeleniteAnimalsApoptosisCells, CulturedLipopolysaccharidesReactive Oxygen SpeciesAnti-Inflammatory AgentsLipopolysaccharidesReactive Oxygen SpeciesSodium SeleniteImmunomodulationInflammationMacrophagesMesenchymal Stem CellsSelenium

Identifiers

PMID42399585
PMCPMC13437566

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.