Evidence map›Paper›PMID 42399772›Full record

ArticleBMC microbiology2026

Analysis of risk factors for carbapenem-resistant Klebsiella pneumoniae bloodstream infections in children: a case-control study.

Jing Jia, Hailing Shi, Panpan Fang, Juanjuan Zhou, Lu Xu, Kaijie Gao, Haizhen Xie, Bing Yang, Mingfa Guo

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Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jing JiaDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.
Hailing ShiDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.
Panpan FangDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.
Juanjuan ZhouDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.
Lu XuDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.
Kaijie GaoDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.
Haizhen XieDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.
Bing YangDepartment of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, China.
Mingfa GuoDepartment of Hematology and Oncology, Children's Hospital Affiliated to Zhengzhou University Key Laboratory of Hematology, Zhengzhou, Henan, 450000, China. guomingfa12@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the risk factors for carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) in children.

methodsA total of 235 pediatric patients with Klebsiella pneumoniae bloodstream infection (KPN-BSI) admitted to our hospital from January 2015 to December 2025 were collected. According to the CLSI criteria, infections in which carbapenem- resistant Klebsiella pneumoniae was isolated from blood culture were defined as CRKP-BSI (n=110), and those in which carbapenem-susceptible Klebsiella pneumoniae was isolated were defined as CSKP-BSI (n=125). We compared clinical profiles of the two groups with the Mann-Whitney U test and chi-square test, and binary logistic regression was used to identify independent risk factors for CRKP-BSI.

resultsChildren with CRKP-BSI were mainly distributed in the Premature Infant Department (49 cases, 44.60 %) and intensive care unit (36 cases, 32.70 %). Analysis of clinical characteristics showed that patient age, underlying diseases, antibiotic use duration ≥ 14 days, mechanical ventilation, surgical procedures during hospitalization, and hospital stay > 5 days were significantly associated with CRKP-BSI (all P < 0.05). Binary logistic regression multivariate analysis demonstrated that the mechanical ventilation (β = 2.896, OR = 18.106), surgical procedures during hospitalization (β = 1.116, OR = 3.052), and hospital stay > 5 days (β = 0.957, OR = 2.603) were independently associated with CRKP-BSI.

conclusionIt is concluded that mechanical ventilation, surgical interventions and prolonged hospitalization independently contribute to the development of CRKP-BSI in children. Enhanced monitoring and precise infection control strategies are required for vulnerable children to prevent CRKP-BSI.

Indexed as

BacteremiaCarbapenem-Resistant EnterobacteriaceaeCarbapenemsKlebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial AgentsCase-Control StudiesChildChild, PreschoolFemaleHumansInfantInfant, NewbornLogistic ModelsMaleRisk FactorsAnti-Bacterial AgentsCarbapenemsBloodstream infectionCarbapenem-resistant Klebsiella pneumoniaeChildren

Identifiers

PMID42399772
PMCPMC13602804

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.