Evidence map›Paper›PMID 42399790›Full record

ArticleThe journal of headache and pain2026

Trigeminovascular calcitonin gene-related peptide release and peripheral vascular responses in a mouse model of accelerated aging: Implications for migraine.

Linda Al-Hassany, Eloisa Rubio-Beltrán, Alejandro Labastida-Ramirez, Ingrid M Garrelds, A H Jan Danser, Anton J M Roks, Antoinette MaassenVanDenBrink

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In one paragraph

Article in The journal of headache and pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linda Al-HassanyDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.
Eloisa Rubio-BeltránDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.
Alejandro Labastida-RamirezDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.
Ingrid M GarreldsDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.
A H Jan DanserDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.
Anton J M RoksDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands.
Antoinette MaassenVanDenBrinkDivision of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands. a.vanharen-maassenvandenbrink@erasmusmc.nl.

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek Vici Grant (09150181910040)
6 · The paper itself

Abstract

objectiveUnderstanding age-related changes in migraine is pivotal, considering the increasing global life expectancy. In addition, both aging and migraine are prominent cardiovascular risk factors. It remains unclear whether calcitonin gene-related peptide (CGRP) release changes with age across trigeminovascular components, and how this relates to peripheral responses to migraine-related vasodilatory molecules. The primary aim was to investigate age-related effects on CGRP release from the trigeminovascular system by studying a mouse model of combined accelerated neuronal and vascular aging, the DNA repair-deficient Ercc1

methodsExperiments were conducted using DNA repair-deficient Ercc1

resultsCGRP release (expressed as ratio compared to baseline release) of the DM was significantly lower in Ercc1

conclusionOur findings suggest that aging is linked to reduced CGRP release of the DM, potentially partly explaining the reduction in migraine attacks in elderly. This decreased CGRP release is not accompanied by altered peripheral vascular reactivity to CGRP.

Indexed as

AgingCalcitonin Gene-Related PeptideCoronary VesselsDura MaterMigraine DisordersTrigeminal GanglionTrigeminal NucleiVasodilationAnimalsColforsinDisease Models, AnimalDNA-Binding ProteinsEndonucleasesMaleMiceMice, Inbred C57BLCalcitonin Gene-Related PeptideColforsinDNA-Binding ProteinsEndonucleasesErcc1 protein, mouseVasodilator AgentsAgingCGRPMiceMigrainePeripheral vasculatureTrigeminovascular system

Identifiers

PMID42399790
PMCPMC13340349

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.