Evidence map›Paper›PMID 42399884›Full record

ArticleBMC biology2026

Associations between immunosenescence and domain-specific cognition in the Health and Retirement Study Harmonized Cognitive Assessment Protocol.

Grace A Noppert, Rebecca C Stebbins, Kelvin Pengyuan Zhang, Lindsay Kobayashi, Kenneth M Langa, Bonnie Levin, Chihua Li, Allison E Aiello

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Grace A NoppertInstitute for Social Research, University of Michigan, 426 Thompson St., Ann Arbor, MI, 48104, USA. gnoppert@umich.edu.
Rebecca C StebbinsRobert N Butler Columbia Aging Center & Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168 St., New York, NY, 10032, USA.
Kelvin Pengyuan ZhangCenter for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Lindsay KobayashiCenter for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.
Kenneth M LangaDepartment of Internal Medicine, University of Michigan Medical School, 1500 E Medical Center Dr., Ann Arbor, MI, 48109, USA.
Bonnie LevinDepartment of Neurology, Miller School of Medicine, University of Miami, 1600 NW 10th Ave, Miami, FL, 33136, USA.
Chihua LiInstitute for Social Research, University of Michigan, 426 Thompson St., Ann Arbor, MI, 48104, USA.
Allison E AielloRobert N Butler Columbia Aging Center & Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168 St., New York, NY, 10032, USA.

Funding

Socioeconomic, Cardiovascular, and Psychosocial Sources of Cross-National Variation in Cognitive Health Among Older AdultsR01AG070953 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alden L. Gross, Lindsay C Kobayashi · 2021 to 2026
$4.6M
Immunosenescence, socioeconomic disadvantage and dementia in the US aging populationR01AG075719 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Allison E Aiello, Grace A Noppert · 2022 to 2026
$3.6M
NIA NIH HHS R01 AG070953NIA NIH HHS R01 AG075719NIH HHS R01 AG070953NIH HHS R01AG075719
6 · The paper itself

Abstract

backgroundAlzheimer's disease and related dementias (ADRD) pose a critical challenge for the aging U.S. population, yet many biological pathways remain unclear. Recent work has focused on whether peripheral immunosenescence contributes to cognitive aging. Using the Health and Retirement Study (HRS), we examined associations between peripheral immunosenescence and domain-specific cognitive function.

resultsImmune function was associated with general and domain-specific cognition, with variation by sex and immune marker. The CD4 + EMRA:Naïve T Cell Ratio, CD4 + Naïve:CD8 + EMRA Ratio, and CMV IgG showed the most consistent associations, particularly with general and executive function. A one-SD increase in CMV IgG was associated with 0.06 SD lower executive function (95% CI: -0.07, -0.05), persisting after adjustment for confounders.

conclusionsAssociations with peripheral immune markers suggest a potential role for peripheral immunosenescence in cognitive aging. The immune system may be an early contributor to cognitive vulnerability, underscoring the need to integrate immune aging into ADRD research.

Indexed as

AgingCognitionCognitive AgingImmunosenescenceAgedAged, 80 and overFemaleHumansMaleDementiaImmunosenescencePopulation health

Identifiers

PMID42399884
PMCPMC13628902

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.