ArticleBMC nutrition2026
Vitamin D deficiency in high-altitude populations: 25(OH)D level and association with systemic inflammation.
Article in BMC nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveThis study aims to investigate the prevalence of serum vitamin D deficiency in the Xining, Qinghai Province (elevation 2260 m, oxygen partial pressure 16.10 kPa, 36°13'-37°28'N) and to explore the correlation between 25-hydroxyvitamin D [25(OH)D] levels and inflammatory markers.
methodsA total of 2,080 subjects were enrolled, serum 25(OH)D, and inflammatory markers-including procalcitonin (PCT), interleukin 6 (IL-6), and C reactive protein (CRP) -were measured. According to serum 25(OH)D concentrations, participants were divided into three groups: vitamin D sufficiency (> 30 ng/mL), insufficiency (20-30 ng/mL), and deficiency (< 20 ng/mL). Spearman correlation analysis, partial correlation analysis and Logistic regression analysis were performed.
resultsThe mean 25(OH)D concentration was 13.99 ± 7.20 ng/mL, with the proportions of vitamin D deficiency, insufficiency and sufficiency being 83.65%, 13.65% and 2.70%, respectively. The levels of PCT, IL-6 and CRP in the deficiency group were significantly higher than those in the other two groups (P < 0.05). The vitamin D deficiency was higher in females than in males (87.95% vs. 77.47%, P < 0.05). The 25(OH)D level peaked in summer and reached the lowest level in winter (P < 0.05), while no significant intergroup difference was observed across different age groups. PCT, IL-6 and CRP were significantly negatively correlated with 25(OH)D (r=-0.674, -0.533, -0.292, P < 0.01), and these correlations remained significant after adjustment for confounding factors (P < 0.01). Logistic regression analysis revealed that female gender (OR = 4.043), PCT (OR = 2491.808), IL-6 (OR = 1.903) and CRP (OR = 1.608) were independent risk factors for vitamin D deficiency (P < 0.01).
conclusionResidents in high-altitude Xining suffer from severe vitamin D deficiency correlated with heightened inflammation. Female sex and elevated inflammatory biomarkers independently increase deficiency risk, and seasonal sunlight regulates 25(OH)D levels. Gender- and season-specific vitamin D supplementation could mitigate inflammatory load in highland residents.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.