Overexpression of Circular RNA circTTN Promotes Ferroptosis in Sepsis-Induced Cardiomyopathy.

Qian Lei, Danyang Zhao, Zhen Wei, Xue Li, Kunjiao Xue, Tingting Zhang, Juanjuan Lyu

Abstract read

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Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Qian LeiDepartment of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Danyang ZhaoDepartment of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Zhen WeiDepartment of Anesthesiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Xue LiDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Kunjiao XueDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Tingting ZhangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID 0000-0002-7362-6608

Juanjuan LyuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.ORCID 0000-0002-8855-0669

Funding

Clinical Research Program of the People's Republic of China WKZX2023CX170004Fundamental Research Funds for the Central Universities SCU2023G4175National Natural Science Foundation of China 82470290National Natural Science Foundation of China 82572491

6 · The paper itself

Abstract

Sepsis-induced cardiomyopathy (SCM) is one of the common complications caused by sepsis. Despite the higher mortality rate associated with SCM, the pathogenesis of SCM is poorly understood. The study of circular RNA (circRNA) in a variety of diseases has accelerated over recent decades. However, the function of circRNAs in SCM is rarely reported. Here, we found that the circRNA from the TTN gene (circTTN) was increased in the SCM mouse and cell models. Modulation of circTTN affected the characteristics of SCM both in mouse and cell models. The expression of ferroptosis regulators, GPX4 and SLC7A11, in SCM models changes inversely with the level of circTTN. Function analysis revealed that circTTN promotes ferroptosis through binding to heat shock protein family A (HSPA5) protein. This finding may promote knowledge about the pathogenesis of SCM and may be helpful for targeted therapy based on circTTN in the future.

Indexed as

CardiomyopathiesFerroptosisRNA, CircularSepsisAmino Acid Transport System y+AnimalsDisease Models, AnimalGene Expression RegulationHeat-Shock ProteinsHumansMaleMiceMice, Inbred C57BLMyocytes, CardiacPhospholipid Hydroperoxide Glutathione PeroxidaseAmino Acid Transport System y+glutathione peroxidase 4, mouseHeat-Shock ProteinsPhospholipid Hydroperoxide Glutathione PeroxidaseRNA, CircularcircRNAferroptosisheat shock proteinseptic cardiomyopathy

Identifiers

PMID42400251

DOI10.1111/jcmm.71271

PMCPMC13332324

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.