Evidence map›Paper›PMID 42400260›Full record

ArticleGut microbes2026

Vitamin B6 produced by gut microbiome regulates host behavioral phenotypes through dopaminergic metabolism.

Doyeon Kim, Minshu Li, Thi Ha Nguyen, Yu-Jeong Choi, Sojeong Jang, Minhyeong Kim, Young-Kwang Kim, Min-Kyoo Shin, Arvie Camille V de Guzman, Sunghyouk Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Doyeon KimNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.ORCID 0009-0005-5912-3579
Minshu LiNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.
Thi Ha NguyenNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.
Yu-Jeong ChoiNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.
Sojeong JangNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.
Minhyeong KimNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.
Young-Kwang KimNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.
Min-Kyoo ShinNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.
Arvie Camille V de GuzmanNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.
Sunghyouk ParkNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome modulates host neuropathology, but the mechanisms linking specific microbial genes and metabolites to host phenotypes remain poorly defined. Here, we identify microbiome-derived vitamin B6 (VB6) and its biosynthesis gene as key regulators of host dopaminergic homeostasis. Metagenomic analysis of fecal samples from Parkinson's disease (PD) patients revealed enrichment of biosynthetic pathways for pyridoxal-5'-phosphate (PLP), the active form of VB6, and tyrosine decarboxylase genes. Using

Indexed as

DopamineGastrointestinal MicrobiomeParkinson DiseaseVitamin B 6alpha-SynucleinAnimalsBacteriaCaenorhabditis elegansDisease Models, AnimalEscherichia coliFecesHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MaleMiceMice, Inbred C57BLalpha-SynucleinDopamineLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Pyridoxal PhosphateVitamin B 6C. elegansgut microbiomeParkinson’s diseasepyridoxal-5-phosphatevitamin B6

Identifiers

PMID42400260
PMCPMC13348962

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.