ArticleThe European journal of neuroscience2026
Improved Motor Neuron Preservation and Axonal Recovery Following Experimental Sciatic Nerve Repair With Heterologous Fibrin Biopolymer.
Article in The European journal of neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Improved Motor Neuron Preservation and Axonal Recovery Following Experimental Sciatic Nerve Repair With Heterologous Fibrin Biopolymer.The European journal of neuroscience · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
Peripheral nerve injuries severely impair motor function. Although neurorrhaphy is the gold-standard treatment, recovery is often incomplete. The heterologous fibrin biopolymer (HFB), a nonhuman-derived and biocompatible sealant, has shown regenerative potential in neural tissues, but its effects on the spinal cord microenvironment after peripheral nerve injury remain unclear. This study evaluated the chronic regenerative effects of HFB combined with neurorrhaphy after sciatic neurotmesis in rats. Forty adult male Wistar rats were divided into four groups: control, denervated, neurorrhaphy, and neurorrhaphy + HFB. After 120 days, the spinal cord, sciatic nerve, and soleus muscle were analyzed. Neurorrhaphy + HFB had more retrograded label neurons than neurorrhaphy, whereas 3D reconstruction suggests reduced neuronal dispersion compared with neurorrhaphy. HFB also positively modulated glial cells, while improving sciatic nerve integrity, with NF200, S100, and G ratio indicating improved axonal regeneration. Neuromuscular junctions in the HFB-treated group were more organized than those in the neurorrhaphy alone. Overall, findings suggest that HFB acts as a bioactive modulator, preserving central glial homeostasis and enhancing peripheral remyelination and reinnervation, representing a promising adjuvant to overcome the limitations of conventional suture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.