Evidence mapPaperPMID 42400537Full record

ReviewXenotransplantation

Ethical Considerations in Islet Xenotransplantation.

Daniel J Hurst, Alexa Tarzy, Christopher A Bobier, Luz A Padilla, Johannes Kögel, Anthony Merlocco, Raphael P H Meier

Abstract readReview
In one paragraph

Review in Xenotransplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel J HurstDepartment of Medical Education & Scholarship, Rowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.ORCID https://orcid.org/0000-0003-0592-2592
Alexa TarzyRowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.
Christopher A BobierCollege of Medicine, Central Michigan University, Mount Pleasant, Michigan, USA.ORCID https://orcid.org/0000-0003-4194-4721
Luz A PadillaDepartment of Epidemiology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID https://orcid.org/0000-0003-4032-044X
Johannes KögelInstitute of Social Medicine and Health Systems Research, Otto Von Guericke University, Magdeburg, Germany.
Anthony MerloccoLe Bonheur Children's Hospital Center For Bioethics and Health Equity, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0001-6228-0229
Raphael P H MeierDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For the management of type 1 diabetes, islet xenotransplantation has emerged as a potential alternative to lifelong insulin therapy or islet allotransplantation. However, this progress raises significant ethical questions that warrant further exploration. This article will examine the ethical landscape of islet xenotransplantation, highlighting points of convergence and distinction with solid organ xenotransplantation. We focus on four key areas: (i) animal welfare, including the ethical implications of sourcing large numbers of pigs per recipient; (ii) pediatric considerations, given the lifelong impact of early interventions, and the increasing prevalence and burden of pediatric diabetes; (iii) informed consent and obligations for long-term monitoring including sample retention; and (iv) strategies for inclusive public and patient engagement to build trust and transparency.

Indexed as

Diabetes Mellitus, Type 1Islets of Langerhans TransplantationTransplantation, HeterologousAnimalsAnimal WelfareHumansInformed ConsentSwineethicsisletpediatrictype 1 diabetesxenotransplantation

Identifiers

PMID42400537
PMCPMC13332721

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.