1-Palmitoyl-4-piperidinopiperidine exhibits anticancer effects in murine triple-negative breast cancer EO771 cells associated with STAT3 signaling suppression.

Hiroki Yoshioka, Junya Hamanaka, Ayane Horiuchi, Hanane Horita, Rion Uno, Azumi Noguchi, Yuki Matsushita, Masumi Suzui

Abstract read

In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Hiroki YoshiokaDepartment of Hygiene, School of Medicine, Kitasato University, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan. yoshioka.hiroki@kitasato-u.ac.jp.ORCID https://orcid.org/0000-0002-0977-434X

Junya HamanakaDepartment of Hygiene, School of Medicine, Kitasato University, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.

Ayane HoriuchiFaculty of Pharmacy, Gifu University of Medical Science, 4-3-3 Nijigaoka, Kani, Gifu, 509-0293, Japan.

Hanane HoritaDepartment of Hygiene, School of Medicine, Kitasato University, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.

Rion UnoDepartment of Hygiene, School of Medicine, Kitasato University, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa, 252-0374, Japan.

Azumi NoguchiDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8588, Japan.

Yuki MatsushitaDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8588, Japan.

Masumi SuzuiDepartment of Neurotoxicology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Cho Mizuho-Ku, Nagoya, 467-8601, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited therapeutic options. An urgent need thus exists to develop novel therapeutic strategies to treat TNBC. We previously demonstrated that 1‑palmitoyl‑4‑piperidinopiperidine (PPI), a derivative of palmitic acid, exerts anticancer effects against human colon carcinoma cells and human pancreatic ductal adenocarcinoma cells by inhibiting signal transducer and activator of transcription 3 (STAT3) phosphorylation. To date, no studies have assessed PPI potency in murine TNBC EO771 cells. We examined cell viability after treatment with PPI for 48 h, and evaluated the expression levels of apoptosis- and cell cycle-related proteins using immunocytochemistry and western blotting. PPI inhibited cell proliferation in a dose-dependent manner, with an IC

Indexed as

ApoptosisCell cycle arrestPalmitoyl piperidinopiperidineSignal transducer and activator of transcriptionTriple negative breast cancer

Identifiers

PMID42400622

DOI10.1038/s41401-021-00718-0

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.